What does cilastatin mean?
Definitions for cilastatin
cilas·tatin
This dictionary definitions page includes all the possible meanings, example usage and translations of the word cilastatin.
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Wiktionary
cilastatinnoun
A dehydropeptidase inhibitor that is used in association with certain antibiotics to prevent them being inactivated
Wikipedia
Cilastatin
Cilastatin inhibits the human enzyme dehydropeptidase.
Wikidata
Cilastatin
Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity. Another carbapenem, meropenem is resistant to dehydropeptidase; therefore, it can be given without cilastatin.
U.S. National Library of Medicine
Cilastatin
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Numerology
Chaldean Numerology
The numerical value of cilastatin in Chaldean Numerology is: 8
Pythagorean Numerology
The numerical value of cilastatin in Pythagorean Numerology is: 9
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"cilastatin." Definitions.net. STANDS4 LLC, 2024. Web. 5 May 2024. <https://www.definitions.net/definition/cilastatin>.
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