What does cilastatin mean?

Definitions for cilastatin

Here are all the possible meanings and translations of the word cilastatin.


  1. cilastatin(Noun)

    A dehydropeptidase inhibitor that is used in association with certain antibiotics to prevent them being inactivated


  1. Cilastatin

    Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity. Another carbapenem, meropenem is resistant to dehydropeptidase; therefore, it can be given without cilastatin.

U.S. National Library of Medicine

  1. Cilastatin

    A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.


  1. Chaldean Numerology

    The numerical value of cilastatin in Chaldean Numerology is: 8

  2. Pythagorean Numerology

    The numerical value of cilastatin in Pythagorean Numerology is: 9

Images & Illustrations of cilastatin

  1. cilastatincilastatincilastatin


Find a translation for the cilastatin definition in other languages:

Select another language:

Discuss these cilastatin definitions with the community:

Word of the Day

Would you like us to send you a FREE new word definition delivered to your inbox daily?

Please enter your email address:     


Use the citation below to add this definition to your bibliography:


"cilastatin." Definitions.net. STANDS4 LLC, 2018. Web. 23 Feb. 2018. <https://www.definitions.net/definition/cilastatin>.

Are we missing a good definition for cilastatin? Don't keep it to yourself...

Nearby & related entries:

Alternative searches for cilastatin:

Thanks for your vote! We truly appreciate your support.