What does calu-3 mean?
Definitions for calu-3
calu-3
This dictionary definitions page includes all the possible meanings, example usage and translations of the word calu-3.
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Wikipedia
Calu-3
Calu-3 is a human lung cancer cell line commonly used in cancer research and drug development. Calu-3 cells are epithelial and can act as respiratory models in preclinical applications.Calu-3 cells were first derived in 1975 by Germain Trempe and Jorgen Fogh of the Memorial Sloan Kettering Cancer Center. The cells were isolated from the pleural effusion of a 25-year-old Caucasian male with a lung adenocarcinoma. The Calu-3 cell line grows as an adherent monolayer and overexpresses the ERBB2 gene, leading to active ErbB2/Her2. The cells also express CK7, occludin, and E-cadherin. Calu-3 cells also have large amounts of cystic fibrosis transmembrane conductance regulator.Calu-3 cells are commonly used as both in vitro and in vivo models for drug development against lung cancer. The cells have been used in studies of pulmonary drug delivery, demonstrating a capacity to intake low molecular weight substances. Calu-3 cells have served as respiratory models for air intake and lung injury due to their responsiveness to foreign substances. The Calu-3 cell line has shown to be useful in the study of chloride ion secretion by lung epithelial cells. The cells may be used in high-throughput screening applications focused on barrier integrity and surface protein expression of lung cells.
Numerology
Chaldean Numerology
The numerical value of calu-3 in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of calu-3 in Pythagorean Numerology is: 1
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Translations for calu-3
From our Multilingual Translation Dictionary
- ಕ್ಯಾಲು-3Kannada
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"calu-3." Definitions.net. STANDS4 LLC, 2024. Web. 29 Apr. 2024. <https://www.definitions.net/definition/calu-3>.
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