Definitions for calcineurin
cal·cineurin

WiktionaryRate this definition:0.0 / 0 votes

1. calcineurinnoun

   A protein phosphatase that stimulates the growth and differentiation of T cells

WikipediaRate this definition:0.0 / 0 votes

1. Calcineurin

   Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of the T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which include ciclosporin, voclosporin, pimecrolimus and tacrolimus.

WikidataRate this definition:0.0 / 0 votes

1. Calcineurin

   Calcineurin is a protein phosphatase also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase. It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell, cytoplasmic, a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2, which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes cyclosporine, pimecrolimus and tacrolimus.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Calcineurin

   A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

How to pronounce calcineurin?

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Numerology

1. Chaldean Numerology

   The numerical value of calcineurin in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of calcineurin in Pythagorean Numerology is: 1

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Calcineurin
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Calcineurin
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=calcineurin