Definitions for c-peptide
c-peptide

WikipediaRate this definition:0.0 / 0 votes

1. C-peptide

   The connecting peptide, or C-peptide, is a short 31-amino-acid polypeptide that connects insulin's A-chain to its B-chain in the proinsulin molecule. In the context of diabetes or hypoglycemia, a measurement of C-peptide blood serum levels can be used to distinguish between different conditions with similar clinical features. In the insulin synthesis pathway, first preproinsulin is translocated into the endoplasmic reticulum of beta cells of the pancreas with an A-chain, a C-peptide, a B-chain, and a signal sequence. The signal sequence is cleaved from the N-terminus of the peptide by a signal peptidase, leaving proinsulin. After proinsulin is packaged into vesicles in the Golgi apparatus (beta-granules), the C-peptide is removed, leaving the A-chain and B-chain bound together by disulfide bonds, that constitute the insulin molecule.

WikidataRate this definition:0.0 / 0 votes

1. C-peptide

   The connecting peptide, or C-peptide, is a short 31-amino-acid protein that connects insulin's A-chain to its B-chain in the proinsulin molecule. In the insulin synthesis pathway, first preproinsulin is secreted from the beta cells of the pancreas with an A-chain, a C-peptide, a B-chain, and a signal sequence. The signal sequence is cleaved from the N-terminus of the peptide by a signal peptidase, leaving proinsulin. Then the C-peptide is removed, leaving the A-chain and B-chain that constitute the insulin molecule.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. C-Peptide

   The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.

How to pronounce c-peptide?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say c-peptide in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of c-peptide in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of c-peptide in Pythagorean Numerology is: 6

Examples of c-peptide in a Sentence

1. Joshy Jacob:

   You have the message and then you have the little stem that holds it up. The message can change but the stem is the same, and this peptide targets the stem of the hemagglutinin, that's why it's very efficient.

2. Joshy Jacob:

   The frog makes this peptide for its own survival. It never gets influenza.

3. Louise Rollins-Smith:

   The peptide described in the Immunity report is somewhat unusual because of the apparent specificity, if further studies show that it has a low level of cytotoxicity and it can protect in other animal models of influenza, it could be developed as a potential treatment for influenza.

4. Joshy Jacob:

   We have identified a potentially new treatment for H1N1 human influenza virus, which is a peptide that comes from the skin of a frog from southern India.

5. Mansoor Husain:

   This is the first orally-available GLP-1 (glucagon-like peptide-1) receptor agonist and that's a pretty big deal, just being able to take a pill every day makes it much more accessible.

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/C-Peptide
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=c-peptide