Definitions for bupropion
bupro·pi·on

WiktionaryRate this definition:0.0 / 0 votes

1. bupropionnoun

   An aminoketone antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor and nicotinic antagonist.

WikipediaRate this definition:0.0 / 0 votes

1. Bupropion

   Bupropion, sold under the brand names Wellbutrin and Zyban among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. It is also popular as an add-on medication in the cases of "incomplete response" to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant. Bupropion has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction; it is not associated with weight gain and sleepiness, and it is more effective than SSRIs at improving symptoms of hypersomnia and fatigue. Bupropion does, however, carry a much higher risk of seizure than many other antidepressants and extreme caution must be taken in patients with a history of seizure disorder. Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Raised blood pressure is notable. Rare but serious side effects include seizure, liver toxicity, psychosis, and risk of overdose. Bupropion use during pregnancy may be associated with increased odds of congenital heart defects.Bupropion acts as a norepinephrine–dopamine reuptake inhibitor and a nicotinic receptor antagonist. However, its effects on dopamine are weak. Chemically, bupropion is an aminoketone that belongs to the class of substituted cathinones and more generally that of substituted amphetamines and substituted phenethylamines.Bupropion was invented by Nariman Mehta, who worked at Burroughs Wellcome, in 1969. It was first approved for medical use in the United States in 1985. Bupropion was originally called by the generic name amfebutamone, before being renamed in 2000. In 2020, it was the eighteenth most commonly prescribed medication in the United States, with more than 28 million prescriptions. It is on the World Health Organization's List of Essential Medicines.

WikidataRate this definition:0.0 / 0 votes

1. Bupropion

   Bupropion is a drug that is primarily used as an atypical antidepressant and smoking cessation aid. Marketed as Wellbutrin, Budeprion, Prexaton, Elontril, Aplenzin, or other trade names, it is the fourth-most prescribed antidepressant in the United States, with over 20 million retail prescriptions in 2007. Marketed in lower-dose formulations as Zyban, Voxra, or other names, it is also widely used to reduce nicotine cravings by people who are trying to quit smoking. It is taken in the form of pills, and in the United States is available only by prescription. Bupropion lowers seizure threshold, and its potential to cause seizures has been widely publicized. However, at the recommended dose, the risk of seizures is comparable to that observed for other antidepressants. Bupropion is an effective antidepressant on its own, but it is also popular as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. In contrast to many other antidepressants, bupropion does not cause weight gain or sexual dysfunction. Bupropion was patented in 1969 by Burroughs Wellcome, which later became part of what is now GlaxoSmithKline. It was originally called amfebutamone, before being renamed in 2000. Its chemical name is 3-chloro-N-tert-butyl-β-ketoamphetamine. It is a substituted cathinone, as well as a substituted amphetamine. The drug is a mild psychostimulant. Its primary pharmacological action is norepinephrine-dopamine reuptake inhibition. It binds selectively to the dopamine transporter, but its behavioral effects have largely been attributed to its inhibition of norepinephrine reuptake. It also acts as a nicotinic acetylcholine receptor antagonist. Bupropion belongs to the chemical class of aminoketones and is similar in structure to stimulants such as cathinone and amfepramone, and to phenethylamines in general. Medically, bupropion serves as a non-tricyclic antidepressant fundamentally different from most commonly prescribed antidepressants such as selective serotonin reuptake inhibitors.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Bupropion

   A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.

How to pronounce bupropion?

1. Alex

   US English

   David

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   Mark

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   Daniel

   British

   Libby

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   Mia

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   Karen

   Australian

   Hayley

   Australian

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   Neerja

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How to say bupropion in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of bupropion in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of bupropion in Pythagorean Numerology is: 9

Popularity rank by frequency of use

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Bupropion
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Bupropion
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=bupropion