Definitions for blood-brain barrier
blood-brain bar·ri·er

Princeton's WordNetRate this definition:0.0 / 0 votes

1. blood-brain barriernoun

   a mechanism that creates a barrier between brain tissues and circulating blood; serves to protect the central nervous system

   "the brain was protected from the large molecules of the virus by the blood-brain barrier"

WiktionaryRate this definition:0.0 / 0 votes

1. blood-brain barriernoun

   A structure in the central nervous system (CNS) that keeps various substances found in the bloodstream out of the brain while allowing in the substances essential to metabolic function, e.g. oxygen.

WikipediaRate this definition:0.0 / 0 votes

1. blood-brain barrier

   The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that prevents solutes in the circulating blood from non-selectively crossing into the extracellular fluid of the central nervous system where neurons reside. The blood–brain barrier is formed by endothelial cells of the capillary wall, astrocyte end-feet ensheathing the capillary, and pericytes embedded in the capillary basement membrane. This system allows the passage of some small molecules by passive diffusion, as well as the selective and active transport of various nutrients, ions, organic anions, and macromolecules such as glucose and amino acids that are crucial to neural function.The blood–brain barrier restricts the passage of pathogens, the diffusion of solutes in the blood, and large or hydrophilic molecules into the cerebrospinal fluid, while allowing the diffusion of hydrophobic molecules (O2, CO2, hormones) and small non-polar molecules. Cells of the barrier actively transport metabolic products such as glucose across the barrier using specific transport proteins. The barrier also restricts the passage of peripheral immune factors, like signaling molecules, antibodies, and immune cells, into the CNS, thus insulating the brain from damage due to peripheral immune events.Specialized brain structures participating in sensory and secretory integration within brain neural circuits—the circumventricular organs and choroid plexus—have in contrast highly permeable capillaries.

ChatGPTRate this definition:0.0 / 0 votes

1. blood-brain barrier

   The blood-brain barrier is a semi-permeable barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system. It is composed of high-density cells restricting passage of substances from the bloodstream much more than do the endothelial cells in capillaries elsewhere in the body, thereby protecting the brain from potential harm. This barrier allows the passage of water, some gases and lipid soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are required for neural function.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Blood-Brain Barrier

   Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.

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1. • Barrier

How to pronounce blood-brain barrier?

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How to say blood-brain barrier in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of blood-brain barrier in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of blood-brain barrier in Pythagorean Numerology is: 1

Examples of blood-brain barrier in a Sentence

1. RAS CARDO REGGAE:

   My quotes are like an endless stream in the reality of life. Those who learn from what I share become the ground penetrating, mesmerizing forces, seen but unseen, to which no technology can detect. The forces which traverses the blood brain barrier leaving no visible mark on the M.R.I images.

2. Paul Rose:

   It was those iconic images of the dead albatross chicks on the Pacific Islands with their stomachs open and all recognizable plastic items inside it, and most recently, it's been when we discovered the nano-particles do cross the blood-brain barrier, and we were able to prove that plastic is in us.

3. Eric Leuthardt:

   What's interesting is that the blood-brain barrier is a two-way street, by breaking it down, you can get things into the brain, but also by breaking it down now things can go from your brain out into your circulation, to your peripheral system, which includes your immune system.

4. The Byers:

   The struggle with Sanfilippo is there’s a lot of the cell waste from the disorder in the brain, and the problem with treating it in the past is they can’t get the enzymes past the blood brain barrier. We’re waiting to see if this trial has figured it out.

5. Kevin Hrusovsky:

   Nobody thought that many of the proteins or bio markers that affect the brain would even be in blood. It was thought, basically, that those proteins and those markers would only be in the brain in the spinal fluid, but what we’ve learned is that a small amount of the spinal fluid, the cerebral spinal fluid, actually leaks into the blood through the blood brain barrier and because our technology can detect things that are so minute in blood, we can test what’s going on in the brain.

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=blood-brain barrier
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Blood-Brain_Barrier
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Blood-Brain_Barrier
4. ^ ChatGPT
   https://chat.openai.com