Definitions for autopharmacology
au·tophar·ma·col·o·gy

WikipediaRate this definition:0.0 / 0 votes

1. Autopharmacology

   Autopharmacology relates to the scientific study of the regulation of body functions by the activity of its naturally existent (or endogenous) chemical factors of the tissues. A more restricted definition would consider substances that were first identified as external agents which had a documented action on physiological functions, but later were discovered as existing as endogenous factors. The best example is the class of endorphins, which, as its name implies, were discovered to exist in the brain and have specific receptors in it, by investigations on the mechanism of action of opioids, such as morphine. Historically, the first approach to the concept of autopharmacology began with British physiologist and pharmacologist Henry Dale in the 1910s, discovered the role of acetylcholine in synaptic transmission, and later proved by Austrian physiologist Otto Loewi, to be the neurotransmitter involved in the proximal synapses of the autonomic nervous system (initially named Vagusstoff by Loewi, and later identified as acetylcholine). The same happened to another autonomic neurotransmitter, noradrenaline (Akzeleransstoff by Loewi), which later proved to be chemically similar to a long used pharmacological agent, adrenaline, a hormone secreted by the adrenal glands. Both scientists were awarded the 1936 Nobel Prize for Physiology or Medicine for their pioneering and important contributions. A research area where autopharmacology principles assumed great importance was that of pain and inflammation, due to the great number of endogenous messengers, transmitters and modulators involved in their complex response at molecular and cellular level. The control and regulation mechanisms of the circulatory system and renal functions and their interactions (such as the renin/angiotensin system) are also greatly influenced by autopharmacological agents; One of the autopharmacology pioneers was Professor Mauricio Rocha e Silva, leader of the team of Brazilian researchers who discovered bradykinin in 1948, an endogenous substance involved in hypotension in circulatory shock. Of course, all these systems are of extreme importance for clinical practice and for the discovery of new therapeutic drugs.

How to pronounce autopharmacology?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say autopharmacology in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of autopharmacology in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of autopharmacology in Pythagorean Numerology is: 2

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Autopharmacology