Definitions for anaplasia
ˌæn əˈpleɪ ʒə, -ʒi əanapla·si·a

Princeton's WordNetRate this definition:0.0 / 0 votes

1. anaplasianoun

   loss of structural differentiation within a cell or group of cells often with increased capacity for multiplication, as in a malignant tumor

WiktionaryRate this definition:0.0 / 0 votes

1. anaplasianoun

   A reversion of differentiation in cells that is characteristic of malignancy in tumours

ChatGPTRate this definition:0.0 / 0 votes

1. anaplasia

   Anaplasia is a medical term referring to cells that have lost the structural and functional characteristics of the mature cells they were derived from, often occurring in malignant tumors. This typically leads to a high rate of cell division and growth, creating cells with irregular sizes and shapes, and contributing significantly to the severity of cancer. Anaplasia is associated with a poor prognosis.

WikidataRate this definition:0.0 / 0 votes

1. Anaplasia

   Anaplasia refers to a reversion of differentiation in cells and is characteristic of malignant neoplasms. Sometimes, the term also includes an increased capacity for multiplication. Lack of differentiation is considered a hallmark of aggressive malignancies. The term anaplasia literally means "to form backward". It implies dedifferentiation, or loss of structural and functional differentiation of normal cells. It is now known, however, that at least some cancers arise from stem cells in tissues; in these tumors failure of differentiation, rather than dedifferentiation of specialized cells, account for undifferentiated tumors. Anaplastic cells display marked pleomorphism. The nuclei are characteristically extremely hyperchromatic and large. The nuclear-cytoplasmic ratio may approach 1:1 instead of the normal 1:4 or 1:6. Giant cells that are considerably larger than their neighbors may be formed and possess either one enormous nucleus or several nuclei. Anaplastic nuclei are variable and bizarre in size and shape. The chromatin is coarse and clumped, and nucleoli may be of astounding size. More important, mitoses are often numerous and distinctly atypical; anarchic multiple spindles may be seen and sometimes appear as tripolar or quadripolar forms. Also, anaplastic cells usually fail to develop recognizable patterns of orientation to one another. They may grow in sheets, with total loss of communal structures, such as gland formation or stratified squamous architecture. Anaplasia is the most extreme disturbance in cell growth encountered in the spectrum of cellular proliferations.

U.S. National Library of MedicineRate this definition:5.0 / 1 vote

1. Anaplasia

   Loss of structural differentiation and useful function of neoplastic cells.

Matched Categories

1. • Dysplasia

How to pronounce anaplasia?

1. Alex

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   Mark

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   Daniel

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   Libby

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How to say anaplasia in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of anaplasia in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of anaplasia in Pythagorean Numerology is: 2

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=anaplasia
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Anaplasia
3. ^ ChatGPT
   https://chat.openai.com
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=anaplasia