Definitions for active site
ac·tive site

Princeton's WordNetRate this definition:0.0 / 0 votes

1. active sitenoun

   the part of an enzyme or antibody where the chemical reaction occurs

WikipediaRate this definition:0.0 / 0 votes

1. Active site

   In biology and biochemistry, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of amino acid residues that form temporary bonds with the substrate (binding site) and residues that catalyse a reaction of that substrate (catalytic site). Although the active site occupies only ~10–20% of the volume of an enzyme,: 19  it is the most important part as it directly catalyzes the chemical reaction. It usually consists of three to four amino acids, while other amino acids within the protein are required to maintain the tertiary structure of the enzymes.Each active site is evolved to be optimised to bind a particular substrate and catalyse a particular reaction, resulting in high specificity. This specificity is determined by the arrangement of amino acids within the active site and the structure of the substrates. Sometimes enzymes also need to bind with some cofactors to fulfil their function. The active site is usually a groove or pocket of the enzyme which can be located in a deep tunnel within the enzyme, or between the interfaces of multimeric enzymes. An active site can catalyse a reaction repeatedly as residues are not altered at the end of the reaction (they may change during the reaction, but are regenerated by the end). This process is achieved by lowering the activation energy of the reaction, so more substrates have enough energy to undergo reaction.

ChatGPTRate this definition:0.0 / 0 votes

1. active site

   An active site is a specific region on an enzyme where a substrate binds and a chemical reaction occurs. This site is crucial for the enzyme's catalytic function as it often contains amino acid residues that directly participate in making and breaking of chemical bonds, leading to formation of a product.

WikidataRate this definition:0.0 / 0 votes

1. Active site

   In biology, the active site is the small portion of an enzyme where substrate molecules bind and undergo a chemical reaction. This chemical reaction occurs when a substrate collides with and slots into the active site of an enzyme. The active site is usually found in a 3-D groove or pocket of the enzyme, lined with amino acid residues. These residues are involved in recognition of the substrate. Residues that directly participate in the catalytic reaction mechanism are called active site residues. After an active site has been involved in a reaction, it can be used again.

Matched Categories

1. • Enzyme
   • Site

How to pronounce active site?

1. Alex

   US English

   David

   US English

   Mark

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   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

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   Neerja

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   Zira

   US English

   Oliver

   British

   Wendy

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   South African

How to say active site in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of active site in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of active site in Pythagorean Numerology is: 5

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=active site
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Active_Site
3. ^ ChatGPT
   https://chat.openai.com
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=active site