Definitions for Tacrolimus
tacrolimus

WiktionaryRate this definition:0.0 / 0 votes

1. tacrolimusnoun

   An immunosuppressive drug used mainly after organ transplantation.

2. Etymology: From tsukuba macrolide immunosuppressant (after Streptomyces tsukubaensis).

WikipediaRate this definition:0.0 / 0 votes

1. Tacrolimus

   Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. For example, it is prescribed for severe refractory uveitis after a bone marrow transplant, exacerbations of minimal change disease, Kimura's disease, and vitiligo. It can be used to treat dry eye syndrome in cats and dogs.Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, as part of the body's learned (or adaptive) immune response. Chemically, it is a macrolide lactone that was first discovered in 1987, from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubensis. It is on the World Health Organization's List of Essential Medicines.

WikidataRate this definition:5.0 / 1 vote

1. Tacrolimus

   Tacrolimus is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It is also used in a topical preparation in the treatment of atopic dermatitis, severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, and the skin condition vitiligo. It is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 production by T-cells.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Tacrolimus

   A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.

How to pronounce Tacrolimus?

1. Alex

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Numerology

1. Chaldean Numerology

   The numerical value of Tacrolimus in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of Tacrolimus in Pythagorean Numerology is: 5

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Tacrolimus
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Tacrolimus
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=Tacrolimus