Definitions for MEDIATOR
ˈmi diˌeɪ tərMEDIATOR

Princeton's WordNet(0.00 / 0 votes)Rate this definition:

1. mediator, go-between, intermediator, intermediary, intercessornoun

   a negotiator who acts as a link between parties

Wiktionary(4.00 / 1 vote)Rate this definition:

1. mediatornoun

   One who negotiates between parties seeking mutual agreement

2. Etymology: mediator, from mediatum, supine of medio, from medius.

Webster Dictionary(0.00 / 0 votes)Rate this definition:

1. Mediatornoun

   one who mediates; especially, one who interposes between parties at variance for the purpose of reconciling them; hence, an intercessor

2. Etymology: [L. mediator: cf. E. mdiateur.]

Freebase(0.00 / 0 votes)Rate this definition:

1. Mediator

   Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered by Roger D. Kornberg, winner of the 2006 Nobel Prize in Chemistry. It is also referred to in scientific literature as the Vitamin D Receptor Interacting Protein coactivator complex and the Thyroid Hormone Receptor-associated Proteins. The Mediator complex is required for the successful transcription of nearly all class II gene promoters in yeast. It works in the same manner in mammals. The human Mediator complex has 26+ subunits and is 1.2 MDa in size. Its large surface area provides great potential for protein–protein interaction, even though its sequences do not contain many predicted functional domains. Mediator has been shown to associate with general transcription factors, as well as RNA polymerase II, and is essential for activator-dependent transcription. It has also been demonstrated that the Mediator complex is involved in activator-independent transcription, implying that it may provide a fundamental control of the formation of the initiation complex. Mediator functions as a coactivator and binds to the C-terminal domain of RNA polymerase II holoenzyme, acting as a bridge between this enzyme and transcription factors.

Military Dictionary and Gazetteer(0.00 / 0 votes)Rate this definition:

1. mediator

   Any state or power which interferes to adjust a quarrel between any two or more powers, is called a mediator.

How to pronounce MEDIATOR?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say MEDIATOR in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of MEDIATOR in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of MEDIATOR in Pythagorean Numerology is: 4

Examples of MEDIATOR in a Sentence

1. Ludwig van Beethoven:

   Music, verily, is the mediator between intellectual and sensuous life... the one incorporeal entrance into the higher world of knowledge which comprehends mankind but which mankind cannot comprehend.

2. Abdulkarim Sadiq:

   The United Nations did not play the role of mediator, it was biased towards the east, they cannot bring peace to Libya – they just add fuel to the fire.

3. Lu Chao:

   The stability of the Korean Peninsula and realizing denuclearization are of vital importance to China, china intends to play an important role as a mediator.

4. New York:

   Rather than championing shutdowns, she’s spent much of her energy, both in public and behind the scenes, trying to get schools open. And she’s been trying, sometimes uncomfortably, to act as a mediator between desperate parents grieving their kids’ interrupted educations and beleaguered teachers who feel they’re being blamed for a calamity they didn’t create.

5. Maria Joao de Conceicao:

   I think Marcelo is what Portugal needs now, both as mediator and a bit of a counterweight to the left.

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