Definitions for GALANTAMINE
galan·tamine

WiktionaryRate this definition:0.0 / 0 votes

1. galantaminenoun

   An alkaloid, obtained synthetically or from various plants, used for the treatment of mild to moderate Alzheimer's disease and various memory impairments.

WikipediaRate this definition:0.0 / 0 votes

1. Galantamine

   Galantamine is used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments. It is an alkaloid that has been isolated from the bulbs and flowers of Galanthus nivalis (Common snowdrop), Galanthus caucasicus (Caucasian snowdrop), Galanthus woronowii (Voronov's snowdrop), and some other members of the family Amaryllidaceae, such as Narcissus (daffodil), Leucojum aestivum (snowflake), and Lycoris including Lycoris radiata (red spider lily). It can also be produced synthetically. Studies of usage in modern medicine began in the Soviet Union in the 1950s. Galantamine was isolated for the first time from bulbs of Galanthus nivalis (common snowdrop) by the Bulgarian chemist D. Paskov and his team in 1956. The active ingredient was extracted, identified, and studied, in particular in relation to its acetylcholinesterase (AChE)-inhibiting properties. The first industrial process was developed in 1959. However, it was not until the 1990s when full-scale synthesis was upscaled and optimized.Since the alkaloid was isolated from a botanical source, it only had contents around 0.1%, which caused the yield to also be extremely low—in the single digits.

WikidataRate this definition:0.0 / 0 votes

1. Galantamine

   Galantamine is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin. It is an alkaloid that is obtained synthetically or from the bulbs and flowers of Galanthus caucasicus, Galanthus woronowii and related genera like Narcissus, Leucojum, and Lycoris including Lycoris radiata. Studies of usage in modern medicine began in the Soviet Union in the 1950s. The active ingredient was extracted, identified, and studied, in particular in relation to its acetylcholinesterase-inhibiting properties. The bulk of the work was carried out by Soviet pharmacologists M. D. Mashkovsky and R. P. Kruglikova–Lvova, beginning in 1951. The work of Mashkovsky and Kruglikova-Lvova was the first published work that demonstrated the AChE-inhibiting properties of galantamine. The first industrial process was developed in Bulgaria by prof. Paskov in 1959 from a species traditionally used as a popular medicine in Eastern Europe, and, thus, the idea for developing a medicine from these species seems to be based on the local use.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Galantamine

   A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.

How to pronounce GALANTAMINE?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say GALANTAMINE in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of GALANTAMINE in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of GALANTAMINE in Pythagorean Numerology is: 7

Popularity rank by frequency of use

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Galantamine
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Galantamine
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=GALANTAMINE