Definitions of zidovudine [ɪˈdoʊ vyuˌdin]

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Definition of 'zidovudine'

Random House Webster's College Dictionary

1. (n.) zidovudine
the international generic term for azidothymidine.

Etymology: (1986; of undetermined orig.)

Definition of 'zidovudine'

Princeton's WordNet

1. (noun) zidovudine, Retrovir, ZDV, AZT
an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow

Definition of 'zidovudine'

U.S. National Library of Medicine

1. zidovudine
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.

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