Definitions for zalcitabine
The compound 2'-3'-dideoxycytidine, a nucleoside analog reverse transcriptase inhibitor, formerly used in antiretroviral therapy
U.S. National Library of Medicine
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.