Definitions for zalcitabine
This page provides all possible meanings and translations of the word zalcitabine
The compound 2'-3'-dideoxycytidine, a nucleoside analog reverse transcriptase inhibitor, formerly used in antiretroviral therapy
Zalcitabine, also called dideoxycytidine, is a nucleoside analog reverse transcriptase inhibitor sold under the trade name Hivid. The recommended dosage is 0.750 mg every 8 hours, as part of a combination regimen. Zalcitabine appears less potent than some other nucleoside RTIs, has an inconvenient three-times daily frequency and is associated with serious adverse events. For these reasons it is now rarely used to treat human immunodeficiency virus, and even removed from pharmacies entirely in some countries.
U.S. National Library of Medicine
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
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