Definitions for xorphanol
xor·phanol

WiktionaryRate this definition:0.0 / 0 votes

1. xorphanolnoun

   An opioid analgesic of the morphinan family.

WikipediaRate this definition:0.0 / 0 votes

1. Xorphanol

   Xorphanol (INN) (developmental code name TR-5379 or TR-5379M), also known as xorphanol mesylate (USAN), is an opioid analgesic of the morphinan family that was never marketed.Xorphanol is a mixed agonist–antagonist of opioid receptors, acting preferentially as a high-efficacy partial agonist/near-full agonist of the κ-opioid receptor (Ki = 0.4 nM; EC50 = 3.3 nM; Imax = 49%; IA = 0.84) and to a lesser extent as a partial agonist of the μ-opioid receptor (Ki = 0.25 nM; IC50 = 3.4 nM; Imax = 29%) with lower relative intrinsic activity and marked antagonistic potential (including the ability to antagonize morphine-induced effects and induce opioid withdrawal in opioid-dependent individuals). The drug has also been found to act as an agonist of the δ-opioid receptor (Ki = 1.0 nM; IC50 = 8 nM; Imax = 76%).Xorphanol produces potent analgesia, and was originally claimed to possess a minimal potential for dependence or abuse. Moreover, side effects in animal studies were relatively mild, with only sedation and nausea being prominent, although it also produced convulsions at the highest dose tested. However, human trials revealed additional side effects such as headaches and euphoria, and this was the subject of a lawsuit between the drug's inventors and the company to which they had licensed the marketing rights, which claimed that these side effects had not been revealed to them during the license negotiations. As a result of this dispute, the drug was never marketed commercially.

WikidataRate this definition:0.0 / 0 votes

1. Xorphanol

   Xorphanol is an opioid analgesic from the morphinan family of drugs. It is a mixed agonist–antagonist at the μ-opioid receptor and produces potent analgesic effects with little potential for dependence or abuse. Side effects in animal studies were relatively mild, with only sedation and nausea being prominent, although it also produced convulsions at the highest dose tested. However human trials revealed additional side effects such as headaches and euphoria, and this was the subject of a lawsuit between the drug's inventors and the company to which they had licensed the marketing rights, which claimed that these side effects had not been revealed to them during the license negotiations. This dispute resulted in the drug never being marketed commercially, although it is still used in scientific research.

How to pronounce xorphanol?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say xorphanol in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of xorphanol in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of xorphanol in Pythagorean Numerology is: 6

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Xorphanol
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Xorphanol
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=xorphanol