Definitions for p-glycoproteins
This page provides all possible meanings and translations of the word p-glycoproteins
U.S. National Library of Medicine
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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"p-glycoproteins." Definitions.net. STANDS4 LLC, 2014. Web. 10 Mar. 2014. <http://www.definitions.net/definition/p-glycoproteins>.