Definitions for osteopontin
This page provides all possible meanings and translations of the word osteopontin
A sialopontin found in bone tissue
Osteopontin, also known as bone sialoprotein I, early T-lymphocyte activation, secreted phosphoprotein 1, 2ar and Rickettsia resistance, is a human gene product, which is also conserved in other species. Osteopontin is a SIBLING glycoprotein that was first identified in 1986 in osteoblasts. The prefix of the word "osteo" indicates that the protein is expressed in bone, although it is also expressed in other tissues. The suffix "-pontin" is derived from "pons," the Latin word for bridge, and signifies osteopontin's role as a linking protein. Osteopontin is an extracellular structural protein and therefore an organic component of bone. Synonyms for this protein include sialoprotein I and 44K BPP. The gene has 7 exons, spans 5 kilobases in length and in humans it is located on the long arm of chromosome 4 region 13. The protein is composed of ~300 amino acids residues and has ~30 carbohydrate residues attached including 10 sialic acid residues, which are attached to the protein during post-translational modification in the Golgi apparatus. The protein is rich in acidic residues: 30-36% are either aspartic or glutamic acid.
U.S. National Library of Medicine
A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
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