What does neurofibromatosis mean?
Definitions for neurofibromatosis
ˌnʊər oʊ faɪˌbroʊ məˈtoʊ sɪs, ˌnyʊər-neu·rofi·bro·mato·sis
This dictionary definitions page includes all the possible meanings, example usage and translations of the word neurofibromatosis.
Princeton's WordNet
neurofibromatosis, von Recklinghausen's diseasenoun
autosomal dominant disease characterized by numerous neurofibromas and by spots on the skin and often by developmental abnormalities
Wiktionary
neurofibromatosisnoun
A genetic disorder characterized by the presence of multiple neurofibromas under the skin
Wikipedia
Neurofibromatosis
Neurofibromatosis (NF) is a group of three conditions in which tumors grow in the nervous system. The three types are neurofibromatosis type I (NF1), neurofibromatosis type II (NF2), and schwannomatosis. In NF1 symptoms include light brown spots on the skin, freckles in the armpit and groin, small bumps within nerves, and scoliosis. In NF2, there may be hearing loss, cataracts at a young age, balance problems, flesh colored skin flaps, and muscle wasting. In schwannomatosis there may be pain either in one location or in wide areas of the body. The tumors in NF are generally non-cancerous.The cause is a genetic mutation in certain oncogenes. These can be inherited, or in about half of cases spontaneously occur during early development. Different mutations result in the three types of NF. Neurofibromatosis arise from the supporting cells of the nervous system rather than the neurons themselves. In NF1, the tumors are neurofibromas (tumors of the peripheral nerves), while in NF2 and schwannomatosis tumors of Schwann cells are more common. Diagnosis is typically based on symptoms, examination, medical imaging, and biopsy. Genetic testing may rarely be done to support the diagnosis.There is no known prevention or cure. Surgery may be done to remove tumors that are causing problems or have become cancerous. Radiation and chemotherapy may also be used if cancer occurs. A cochlear implant or auditory brainstem implant may help some who have hearing loss due to the condition.In the United States, about 1 in 3,500 people have NF1 and 1 in 25,000 have NF2. Males and females are affected equally often. In NF1, symptoms are often present at birth or develop before 10 years of age. While the condition typically worsens with time, most people with NF1 have a normal life expectancy. In NF2, symptoms may not become apparent until early adulthood. NF2 increases the risk of early death. Descriptions of the condition occur as far back as the 1st century. It was formally described by Friedrich Daniel von Recklinghausen in 1882, after whom it was previously named.
ChatGPT
neurofibromatosis
Neurofibromatosis is a group of genetic disorders that primarily affect the development and growth of nerve cell tissues. These disorders cause tumors to grow on nerves and produce other abnormalities such as skin changes and bone deformities. There are three types namely: Neurofibromatosis type 1 (NF1), Neurofibromatosis type 2 (NF2) and Schwannomatosis. Symptoms and severity can vary greatly among individuals, even within the same family. Currently, there's no cure for neurofibromatosis, but treatments can help manage symptoms and complications.
Wikidata
Neurofibromatosis
Neurofibromatosis is a genetically-inherited disorder in which the nerve tissue grows tumors that may be benign and may cause serious damage by compressing nerves and other tissues. The disorder affects all neural crest cells. Cellular elements from these cell types proliferate excessively throughout the body, forming tumors; melanocytes also function abnormally in this disease, resulting in disordered skin pigmentation and café au lait spots. The tumors may cause bumps under the skin, colored spots, skeletal problems, pressure on spinal nerve roots, and other neurological problems. Neurofibromatosis is an autosomal dominant disorder, which means only one copy of the affected gene is needed for the disorder to develop. Therefore, if only one parent has neurofibromatosis, his or her children have a 50% chance of developing the condition as well. The severity in affected individuals can vary; this may be due to variable expressivity. Approximately half of cases are due to de novo mutations and no other affected family members are seen. It affects males and females equally.
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Numerology
Chaldean Numerology
The numerical value of neurofibromatosis in Chaldean Numerology is: 5
Pythagorean Numerology
The numerical value of neurofibromatosis in Pythagorean Numerology is: 3
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Translations for neurofibromatosis
From our Multilingual Translation Dictionary
- neurofibromatosiCatalan, Valencian
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"neurofibromatosis." Definitions.net. STANDS4 LLC, 2024. Web. 18 Mar. 2024. <https://www.definitions.net/definition/neurofibromatosis>.
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