Definitions for minimisation

This page provides all possible meanings and translations of the word minimisation

Princeton's WordNet

  1. minimization, minimisation(noun)

    the act of reducing something to the least possible amount or degree or position

Freebase

  1. Minimisation

    Minimisation is a method of adaptive stratified sampling that is used in clinical trials, as described by Pocock and Simon. The aim of minimisation is to minimise the imbalance between the number of patients in each treatment group over a number of factors. Normally patients would be allocated to a treatment group randomly and while this maintains a good overall balance, it can lead to imbalances within sub-groups. For example if a majority of the patients who were receiving the active drug happened to be male, or smokers, the statistical usefulness of the study would be reduced. The traditional method to avoid this problem, known as blocked randomisation, is to stratify patients according to a number of factors and to use a separate randomisation list for each group. Each randomisation list would be created such that after every block of x patients, there would be an equal number in each treatment group. The problem with this method is that the number of lists increases exponentially with the number of stratification factors. Minimisation addresses this problem by calculating the imbalance within each factor should the patient be allocated to a particular treatment group. The various imbalances are added together to give the overall imbalance in the study. The treatment group that would minimise the imbalance can be chosen directly, or a random element may be added.

Translation

Find a translation for the minimisation definition in other languages:

Select another language:

Discuss these minimisation definitions with the community:


Citation

Use the citation below to add this definition to your bibliography:

Style:MLAChicagoAPA

"minimisation." Definitions.net. STANDS4 LLC, 2014. Web. 29 Aug. 2014. <http://www.definitions.net/definition/minimisation>.

Are we missing a good definition for minimisation?


The Web's Largest Resource for

Definitions & Translations


A Member Of The STANDS4 Network


Nearby & related entries:

Alternative searches for minimisation: