Definitions for cilastatin
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Wiktionary
cilastatin(Noun)
A dehydropeptidase inhibitor that is used in association with certain antibiotics to prevent them being inactivated
U.S. National Library of Medicine
Cilastatin
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
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