Definitions for cilastatin

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Wiktionary

  1. cilastatin(Noun)

    A dehydropeptidase inhibitor that is used in association with certain antibiotics to prevent them being inactivated

Freebase

  1. Cilastatin

    Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity. Another carbapenem, meropenem is resistant to dehydropeptidase; therefore, it can be given without cilastatin.

U.S. National Library of Medicine

  1. Cilastatin

    A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

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