Definitions for 4-hydroxycoumarins
This page provides all possible meanings and translations of the word 4-hydroxycoumarins
U.S. National Library of Medicine
Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.
4-Hydroxycoumarins are a class of vitamin K antagonist anticoagulant drug molecules derived from coumarin by adding a hydroxy group at the 4 position to obtain "4-hydroxycoumarin", then adding a large aromatic substituent at the 3-position. The large 3-position substituent is required for anticoagulant activity. The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. These compounds are not direct antagonists of vitamin K, but rather act to deplete reduced vitamin K in tissues. For this reason vitamin K antagonizes their effect, and this has led to the loose terminology of vitamin K antagonism.
Find a translation for the 4-hydroxycoumarins definition in other languages:
Select another language:
Discuss these 4-hydroxycoumarins definitions with the community:
Use the citation below to add this definition to your bibliography:
"4-hydroxycoumarins." Definitions.net. STANDS4 LLC, 2014. Web. 9 Mar. 2014. <http://www.definitions.net/definition/4-hydroxycoumarins>.