What does 4-hydroxycoumarins mean?
Definitions for 4-hydroxycoumarins
4-hydrox·y·coumarins
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Wikipedia
4-Hydroxycoumarins
4-Hydroxycoumarins belong to a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin by adding a hydroxy group at the 4 position to obtain 4-hydroxycoumarin, then adding a large aromatic substituent at the 3-position (the ring-carbon between the hydroxyl and the carbonyl). The large 3-position substituent is required for anticoagulant activity. The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. These compounds are not direct antagonists (in the pharmaceutical sense) of vitamin K, but rather act to deplete reduced vitamin K in tissues. For this reason vitamin K antagonizes their effect, and this has led to the loose terminology of vitamin K antagonism.
Wikidata
4-Hydroxycoumarins
4-Hydroxycoumarins are a class of vitamin K antagonist anticoagulant drug molecules derived from coumarin by adding a hydroxy group at the 4 position to obtain "4-hydroxycoumarin", then adding a large aromatic substituent at the 3-position. The large 3-position substituent is required for anticoagulant activity. The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. These compounds are not direct antagonists of vitamin K, but rather act to deplete reduced vitamin K in tissues. For this reason vitamin K antagonizes their effect, and this has led to the loose terminology of vitamin K antagonism.
U.S. National Library of Medicine
4-Hydroxycoumarins
Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.
Numerology
Chaldean Numerology
The numerical value of 4-hydroxycoumarins in Chaldean Numerology is: 3
Pythagorean Numerology
The numerical value of 4-hydroxycoumarins in Pythagorean Numerology is: 7
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"4-hydroxycoumarins." Definitions.net. STANDS4 LLC, 2024. Web. 26 Apr. 2024. <https://www.definitions.net/definition/4-hydroxycoumarins>.
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