Definitions for 1-methyl-4-phenylpyridinium
MPP+, the active metabolite of MPTP.
A neurotoxin which cannot cross the blood brain barrier, but once in contact it can destroy the dopaminergic neurons of the substantia nigra.
U.S. National Library of Medicine
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
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