What does 1-methyl-4-phenylpyridinium mean?
Definitions for 1-methyl-4-phenylpyridinium
1-methyl-4-phenylpyri·dini·um
This dictionary definitions page includes all the possible meanings, example usage and translations of the word 1-methyl-4-phenylpyridinium.
Wiktionary
1-methyl-4-phenylpyridiniumnoun
MPP+, the active metabolite of MPTP.
1-methyl-4-phenylpyridiniumnoun
A neurotoxin which cannot cross the blood brain barrier, but once in contact it can destroy the dopaminergic neurons of the substantia nigra.
Wikipedia
1-methyl-4-phenylpyridinium
MPP+ (1-methyl-4-phenylpyridinium) is a positively charged organic molecule with the chemical formula C12H12N+. It is a neurotoxin that acts by interfering with oxidative phosphorylation in mitochondria by inhibiting complex I, leading to the depletion of ATP and eventual cell death.MPP+ arises in the body as the toxic metabolite of the closely related compound MPTP. MPTP is converted in the brain into MPP+ by the enzyme MAO-B, ultimately causing parkinsonism in primates by killing certain dopamine-producing neurons in the substantia nigra. The ability for MPP+ to induce Parkinson's disease has made it an important compound in Parkinson's research since this property was discovered in 1983.The chloride salt of MPP+ found use in the 1970s as an herbicide under the trade name cyperquat. Though no longer in use as an herbicide, cyperquat's closely related structural analog paraquat still finds widespread usage, raising some safety concerns.
U.S. National Library of Medicine
1-Methyl-4-phenylpyridinium
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Numerology
Chaldean Numerology
The numerical value of 1-methyl-4-phenylpyridinium in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of 1-methyl-4-phenylpyridinium in Pythagorean Numerology is: 4
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"1-methyl-4-phenylpyridinium." Definitions.net. STANDS4 LLC, 2024. Web. 27 Apr. 2024. <https://www.definitions.net/definition/1-methyl-4-phenylpyridinium>.
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