Definitions for tumor necrosis factor
tu·mor necro·sis fac·tor

Princeton's WordNetRate this definition:0.0 / 0 votes

1. tumor necrosis factor, tumour necrosis factor, TNFnoun

   a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)

WiktionaryRate this definition:0.0 / 0 votes

1. tumor necrosis factornoun

   Any of several polypeptide hormones, produced by macrophages, that can destroy some cancer cells

WikipediaRate this definition:0.0 / 0 votes

1. Tumor necrosis factor

   Tumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and a cytokine. TNF is a member of the TNF superfamily, which consists of various transmembrane proteins with a homologous TNF domain. As an adipokine, TNF promotes insulin resistance, and is associated with obesity-induced type 2 diabetes. As a cytokine, TNF is used by the immune system for cell signaling. If macrophages (certain white blood cells) detect an infection, they release TNF to alert other immune system cells as part of an inflammatory response.TNF signaling occurs through two receptors: TNFR1 and TNFR2. TNFR1 is constituitively expressed on most cell types, whereas TNFR2 is restricted primarily to endothelial, epithelial, and subsets of immune cells. TNFR1 signaling tends to be pro-inflammatory and apoptotic, whereas TNFR2 signaling is anti-inflammatory and promotes cell proliferation. Suppression of TNFR1 signaling has been important for treatment of autoimmune disease, whereas TNFR2 signaling promotes wound healing.TNF-α exists as a transmembrane form (mTNF-α) and as a soluble form (sTNF-α). sTNF-α results from enzymatic cleavage of mTNF-α, by a process called substrate presentation. mTNF-α is mainly found on monocytes/macrophages where it interacts with tissue receptors by cell-to-cell contact. sTNF-α selectively binds to TNFR1, whereas mTNF-α binds to both TNFR1 and TNFR2. TNF-α binding to TNFR1 is irreversible, whereas binding to TNFR2 is reversible.The primary role of TNF is in the regulation of immune cells. TNF, as an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, and inflammation, inhibit tumorigenesis and viral replication, and respond to sepsis via IL-1 and IL-6-producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression, psoriasis and inflammatory bowel disease (IBD). Though controversial, some studies have linked depression and IBD to increased levels of TNF.Under the name tasonermin, TNF is used as an immunostimulant drug in the treatment of certain cancers. Drugs that counter the action of TNF are used in the treatment of various inflammatory diseases, for instance rheumatoid arthritis. Certain cancers can cause overproduction of TNF. TNF parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

ChatGPTRate this definition:0.0 / 0 votes

1. tumor necrosis factor

   Tumor necrosis factor (TNF) is a cell-signaling protein (cytokine) involved in systemic inflammation and the acute phase response. It plays a central role in immune system regulation, cell survival, inflammation, differentiation, proliferation, and death (apoptosis). TNF is mainly produced by macrophages, but also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and nerve tissue. Dysregulation of TNF production has been implicated in a variety of human diseases, including Alzheimer's disease, cancer, depression, psoriasis, inflammatory bowel disease, and rheumatoid arthritis.

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1. • Cytokine

How to pronounce tumor necrosis factor?

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Numerology

1. Chaldean Numerology

   The numerical value of tumor necrosis factor in Chaldean Numerology is: 5

2. Pythagorean Numerology

   The numerical value of tumor necrosis factor in Pythagorean Numerology is: 9

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=tumor necrosis factor
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Tumor_Necrosis_Factor
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Tumor_Necrosis_Factor
4. ^ ChatGPT
   https://chat.openai.com