What does severe combined immunodeficiency mean?

Definitions for severe combined immunodeficiency
se·vere com·bined im·mun·od·e·fi·cien·cy

This dictionary definitions page includes all the possible meanings, example usage and translations of the word severe combined immunodeficiency.

Princeton's WordNet

  1. severe combined immunodeficiency, severe combined immunodeficiency disease, SCIDnoun

    a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life

Wikipedia

  1. Severe combined immunodeficiency

    Severe combined immunodeficiency (SCID), also known as Swiss-type agammaglobulinemia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in differing clinical presentations. SCID involves defective antibody response due to either direct involvement with B lymphocytes or through improper B lymphocyte activation due to non-functional T-helper cells. Consequently, both "arms" (B cells and T cells) of the adaptive immune system are impaired due to a defect in one of several possible genes. SCID is the most severe form of primary immunodeficiencies, and there are now at least nine different known genes in which mutations lead to a form of SCID. It is also known as the bubble boy disease and bubble baby disease because its victims are extremely vulnerable to infectious diseases and some of them, such as David Vetter, have become famous for living in a sterile environment. SCID is the result of an immune system so highly compromised that it is considered almost absent. SCID patients are usually affected by severe bacterial, viral, or fungal infections early in life and often present with interstitial lung disease, chronic diarrhea, and failure to thrive. Ear infections, recurrent Pneumocystis jirovecii (previously carinii) pneumonia, and profuse oral candidiasis commonly occur. These babies, if untreated, usually die within one year due to severe, recurrent infections unless they have undergone successful hematopoietic stem cell transplantation or gene therapy in clinical trials.

ChatGPT

  1. severe combined immunodeficiency

    Severe Combined Immunodeficiency (SCID) is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations, leading to severely compromised adaptive immunity. This leaves the person vulnerable to infections, including those that would be otherwise minor illnesses in people with a healthy immune system. It is often known as 'bubble boy disease'. Newborns with SCID appear healthy but are highly susceptible to severe infections because of their impaired immune system. If untreated, SCID is usually fatal within the first year of life.

Wikidata

  1. Severe combined immunodeficiency

    Severe combined immunodeficiency, is a genetic disorder characterized by the absence of functional T-lymphocytes, which results in a defective antibody response due to either direct involvement with B lymphocytes or through improper B lymphocyte activation due to non-functional T-helper cells. Consequently, both "arms" of the adaptive immune system are impaired due to a defect in one of several possible genes. SCID is the most severe form of primary immunodeficiencies, and there are now at least nine different known genes in which mutations lead to a form of SCID. It is also known as the bubble boy disease because its victims are extremely vulnerable to infectious diseases and some of them, such as David Vetter, become famous for living in a sterile environment. SCID is the result of an immune system so highly compromised that it is considered almost absent. SCID patients are usually affected by severe bacterial, viral, or fungal infections early in life and often present with interstitial lung disease, chronic diarrhea, and failure to thrive. Ear infections, recurrent Pneumocystis jirovecii pneumonia, and profuse oral candidiasis commonly occur. These babies, if untreated, usually die within 1 year due to severe, recurrent infections unless they have undergone successful Hematopoietic stem cell transplantation.

U.S. National Library of Medicine

  1. Severe Combined Immunodeficiency

    Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).

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Numerology

  1. Chaldean Numerology

    The numerical value of severe combined immunodeficiency in Chaldean Numerology is: 3

  2. Pythagorean Numerology

    The numerical value of severe combined immunodeficiency in Pythagorean Numerology is: 1

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"severe combined immunodeficiency." Definitions.net. STANDS4 LLC, 2024. Web. 21 Jun 2024. <https://www.definitions.net/definition/severe+combined+immunodeficiency>.

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