What does osteogenesis imperfecta mean?

Definitions for osteogenesis imperfecta

Here are all the possible meanings and translations of the word osteogenesis imperfecta.

Princeton's WordNet

  1. osteogenesis imperfecta(noun)

    autosomal dominant disorder of connective tissue characterized by brittle bones that fracture easily


  1. osteogenesis imperfecta(Noun)

    a hereditary disease characterized by brittle bones that easily fracture


  1. Osteogenesis imperfecta

    Osteogenesis imperfecta is a congenital bone disorder. People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of Type-I collagen. This deficiency arises from an amino acid substitution of glycine to bulkier amino acids in the collagen triple helix structure. The larger amino acid side-chains create steric hindrance that creates a bulge in the collagen complex, which in turn influences both the molecular nanomechanics as well as the interaction between molecules, which are both compromised. As a result, the body may respond by hydrolyzing the improper collagen structure. If the body does not destroy the improper collagen, the relationship between the collagen fibrils and hydroxyapatite crystals to form bone is altered, causing brittleness. Another suggested disease mechanism is that the stress state within collagen fibrils is altered at the locations of mutations, where locally larger shear forces lead to rapid failure of fibrils even at moderate loads as the homogeneous stress state found in healthy collagen fibrils is lost. These recent works suggest that OI must be understood as a multi-scale phenomenon, which involves mechanisms at the genetic, nano-, micro- and macro-level of tissues.

U.S. National Library of Medicine

  1. Osteogenesis Imperfecta

    Autosomal dominant COLLAGEN DISEASES resulting from defective biosynthesis of COLLAGEN TYPE I and characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. There are four major types, I-IV.


  1. Chaldean Numerology

    The numerical value of osteogenesis imperfecta in Chaldean Numerology is: 2

  2. Pythagorean Numerology

    The numerical value of osteogenesis imperfecta in Pythagorean Numerology is: 5

Images & Illustrations of osteogenesis imperfecta

  1. osteogenesis imperfecta

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