What does locus control region mean?
Definitions for locus control region
lo·cus con·trol re·gion
This dictionary definitions page includes all the possible meanings, example usage and translations of the word locus control region.
Wikidata
Locus control region
Locus control regions are defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. The concept derives from the idea that developmental and cell lineage-specific regulation of gene expression relies not only on gene-proximal elements such as promoters, enhancers, and silencers, but also on long-range interactions of various cis-regulatory elements and dynamic chromatin alterations. The LCR was identified over 20 years ago. In transgenic mouse studies it was determined that the LCR was required for normal regulation of beta-globin gene expression. Several models exist for how the LCR exerts its effects on transcription from a distance.
U.S. National Library of Medicine
Locus Control Region
A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. The region is believed to regulate GENETIC TRANSCRIPTION by opening and remodeling CHROMATIN structure. It may also have enhancer activity.
Numerology
Chaldean Numerology
The numerical value of locus control region in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of locus control region in Pythagorean Numerology is: 1
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"locus control region." Definitions.net. STANDS4 LLC, 2024. Web. 6 Jun 2024. <https://www.definitions.net/definition/locus+control+region>.
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