What does lactoylglutathione lyase mean?
Definitions for lactoylglutathione lyase
lac·toyl·glu·tathione lyase
This dictionary definitions page includes all the possible meanings, example usage and translations of the word lactoylglutathione lyase.
Wiktionary
lactoylglutathione lyasenoun
A glyoxalase enzyme that catalyzes the isomerization of hemithioacetal adducts.
Wikidata
Lactoylglutathione lyase
In enzymology, a lactoylglutathione lyase is an enzyme that catalyzes the isomerization of hemithioacetal adducts, which are formed in a spontaneous reaction between a glutathionyl group and aldehydes such as methylglyoxal. Glyoxalase I derives its name from its catalysis of the first step in the glyoxalase system, a critical two-step detoxification system for methylglyoxal. Methylglyoxal is produced naturally as a byproduct of normal biochemistry, but is highly toxic, due to its chemical reactions with proteins, nucleic acids, and other cellular components. The second detoxification step, in which-S-lactoylglutathione is split into glutathione and D-lactate, is carried out by glyoxalase II, a hydrolase. Unusually, these reactions carried out by the glyoxalase system does not oxidize glutathione, which usually acts as a redox coenzyme. Although aldose reductase can also detoxify methylgloxal, the glyoxalase system is more efficient and seems to be the most important of these pathways. Glyoxalase I is an attractive target for the development of drugs to treat infections by some parasitic protozoa, and cancer. Several inhibitors of glyoxalase I have been identified, such as S-glutathione.
U.S. National Library of Medicine
Lactoylglutathione Lyase
An enzyme that catalyzes the interconversion of methylglyoxal and lactate, with glutathione serving as a coenzyme. EC 4.4.1.5.
Numerology
Chaldean Numerology
The numerical value of lactoylglutathione lyase in Chaldean Numerology is: 7
Pythagorean Numerology
The numerical value of lactoylglutathione lyase in Pythagorean Numerology is: 3
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"lactoylglutathione lyase." Definitions.net. STANDS4 LLC, 2024. Web. 27 Apr. 2024. <https://www.definitions.net/definition/lactoylglutathione+lyase>.
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