Heavy chain disease
Heavy chain disease is a form of paraproteinemia with a proliferation of cells producing immunoglobulin heavy chains. This disease is characterized by an excessive production of heavy chains that are short and truncated. These heavy chain disease proteins have various deletions, mainly in their amino-terminal part, which causes the heavy chains to lose the ability to form disulfide bonds with the light chains. The defect in the immunoglobulins presumably arises during somatic hypermutation. Deletion of the N-terminal part of the heavy chain disease protein leads to aggregation and signaling of the B cell receptor, presumably due to the loss of the anti-aggregating properties of the light chain.
U.S. National Library of Medicine
Heavy Chain Disease
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
The numerical value of heavy chain disease in Chaldean Numerology is: 1
The numerical value of heavy chain disease in Pythagorean Numerology is: 5
Images & Illustrations of heavy chain disease
Find a translation for the heavy chain disease definition in other languages:
Select another language:
Discuss these heavy chain disease definitions with the community:
Word of the Day
Would you like us to send you a FREE new word definition delivered to your inbox daily?
Use the citation below to add this definition to your bibliography:
"heavy chain disease." Definitions.net. STANDS4 LLC, 2018. Web. 25 Apr. 2018. <https://www.definitions.net/definition/heavy chain disease>.