Hereditary fructose intolerance is an inborn error of fructose metabolism caused by a deficiency of the enzyme aldolase B. Individuals affected with HFI are asymptomatic until they ingest fructose, sucrose, or sorbitol. If fructose is ingested, the enzymatic block at aldolase B causes an accumulation of fructose-1-phosphate. This accumulation has downstream effects on gluconeogenesis and regeneration of adenosine triphosphate. Symptoms of HFI include vomiting, hypoglycemia, jaundice, hemorrhage, hepatomegaly, hyperuricemia and potentially kidney failure. While HFI is not clinically a devastating condition, there are reported deaths in infants and children as a result of the metabolic consequences of HFI. Death in HFI is always associated with problems in diagnosis. HFI is an autosomal recessive condition caused by mutations in the ALDOB gene, located at 9q22.3. Diagnosis of HFI is typically suspected based on dietary history, especially in infants who become symptomatic after breast feeding is supplemented by fructose containing foods. This suspicion is typically confirmed by molecular analysis. Treatment of HFI is based around strict avoidance of fructose in the diet. Older patients with HFI typically self-select a diet low in fructose, even before being diagnosed.
U.S. National Library of Medicine
An autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (EC 126.96.36.199) activity, resulting in accumulation of fructose-1-phosphate. The accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycemia following ingestion of fructose. Prolonged fructose ingestion in infants leads ultimately to hepatic failure and death. Patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet.
The numerical value of fructose intolerance in Chaldean Numerology is: 7
The numerical value of fructose intolerance in Pythagorean Numerology is: 7
Images & Illustrations of fructose intolerance
Find a translation for the fructose intolerance definition in other languages:
Select another language:
Discuss these fructose intolerance definitions with the community:
Word of the Day
Would you like us to send you a FREE new word definition delivered to your inbox daily?
Use the citation below to add this definition to your bibliography:
"fructose intolerance." Definitions.net. STANDS4 LLC, 2018. Web. 26 Apr. 2018. <https://www.definitions.net/definition/fructose intolerance>.