What does xanomeline mean?
Definitions for xanomeline
xanome·line
This dictionary definitions page includes all the possible meanings, example usage and translations of the word xanomeline.
Wiktionary
xanomelinenoun
A muscarinic acetylcholine receptor agonist with reasonable selectivity for the M1 and M4 subtypes, possibly useful in treating Alzheimer's disease and schizophrenia.
Wikipedia
Xanomeline
Xanomeline (LY-246,708; Lumeron, Memcor) is a small molecule muscarinic acetylcholine receptor agonist that was first synthesized in a collaboration between Eli Lilly and Novo Nordisk as an investigational therapeutic being studied for the treatment of central nervous system disorders.Its pharmacological action is mediated primarily through stimulation of central nervous system muscarinic M1 and M4 receptor subtypes. Xanomeline is currently being developed as a combination drug (Kar-XT; xanomeline + trospium) by Karuna Therapeutics. Trospium is a non-CNS penetrant non-selective muscarinic antagonist to quell peripheral muscarinic agonist-dependent side effects. Xanomeline’s mechanism of action is hypothesized to be via rebalancing key neurotransmitter circuits, including acetylcholine, dopamine, and glutamate, which are disrupted in schizophrenia and related diseases.
Wikidata
Xanomeline
Xanomeline is a muscarinic acetylcholine receptor agonist with reasonable selectivity for the M1 and M4 subtypes, though it is also known to act as a M5 receptor antagonist. It has been studied for the treatment of both Alzheimer's disease and schizophrenia, particularly the cognitive and negative symptoms, although gastrointestinal side effects led to a high drop-out rate in clinical trials. Despite this, xanomeline has been shown to have reasonable efficacy for the treatment of schizophrenia symptoms, and one recent human study found robust improvements in verbal learning and short-term memory associated with xanomeline treatment.
Numerology
Chaldean Numerology
The numerical value of xanomeline in Chaldean Numerology is: 5
Pythagorean Numerology
The numerical value of xanomeline in Pythagorean Numerology is: 4
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"xanomeline." Definitions.net. STANDS4 LLC, 2024. Web. 27 Apr. 2024. <https://www.definitions.net/definition/xanomeline>.
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