Definitions for unfolded protein response

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  1. Unfolded Protein Response

    A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.


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"unfolded protein response." STANDS4 LLC, 2015. Web. 30 Mar. 2015. < protein response>.

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