Definitions for u937 cell
u937 cell

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1. u937 cell

   U-937 cells are a pro-monocytic model cell line used in biomedical research. They were isolated from the histiocytic lymphoma of a 37-year-old male patient in 1974. Due to the relative uniformity of expanded cultures and lower maintenance requirements these cells have been since used as an important tool for studying phagocyte differentiation and different kinds of cell-to-cell interactions. U-937 cells mature and differentiate in response to a number of soluble stimuli, adopting the morphology and characteristics of monocytes, macrophages or dendritic cells.U-937 cells are of myeloid lineage and thus secrete a large number of cytokines and chemokines either constitutively (e.g., IL-1 and GM-CSF) or in response to soluble stimuli. TNFα and recombinant GM-CSF for example independently promote IL-10 production in U937 cells. This cell line is therefore widely used for cytokine level read-outs as a result of exposure to various chemical compounds. Namely, production of IL-1β, IL-6, IL-8, IL-10, TNF-α, iNOS, COX-2 and NF-κB is commonly measured.U-937 cells bear the t(10;11)(p13;q14) translocation causing a fusion of MLLT10 and Ap-3-like clathrin assembly protein PICALM. The HLA alleles present in U-937 cells are HLA-A*03:01, A*31:01, B*18:01, B*51:01, Cw*01:02 and Cw*07:02.

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1. U937 cell

   U937 cells are a model cell line used in biomedical research. They were isolated from the histiocytic lymphoma of a 37 year old male patient and are used to study the behaviour and differentiation of monocytes. U937 cells mature and differentiate in response to a number of soluble stimuli, adopting the morphology and characteristics of mature macrophages. U937 cells are of the myeloid lineage and so secrete a large number of cytokines and chemokines either constitutively or in response to soluble stimuli. TNFα and recombinant GM-CSF independently promote IL-10 production in U937 cells. IFNγ increases the expression of chemokine receptors as well as that of nuclear receptors for melatonin. IFNγ treatment enhances thrombin-induced IL-8 production and is required for the melatonin-induced production of IL-6. U937 can be grown in DMEM or 1640 medium plus 10% fetal bovine serum. Atromentin induces apoptosis in human leukemia U937 cells. The HLA alleles present in U937 cells are HLA-A*03:01, A*31:01, B*18:01, B*51:01, Cw*01:02 and Cw*07:02.

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Numerology

1. Chaldean Numerology

   The numerical value of u937 cell in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of u937 cell in Pythagorean Numerology is: 8

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/U937_Cell
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=u937 cell