Definitions for telomerase
təˈlɒm əˌreɪs, -ˌreɪztelom·erase

Princeton's WordNetRate this definition:0.0 / 0 votes

1. telomerasenoun

   an enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide

WiktionaryRate this definition:0.0 / 0 votes

1. telomerasenoun

   An enzyme in eukaryotic cells that adds a specific sequence of DNA to the telomeres of chromosomes after they divide; gives the chromosomes stability over time.

WikipediaRate this definition:0.0 / 0 votes

1. Telomerase

   Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each end of the chromosomes of most eukaryotes. Telomeres protect the end of the chromosome from DNA damage or from fusion with neighbouring chromosomes. The fruit fly Drosophila melanogaster lacks telomerase, but instead uses retrotransposons to maintain telomeres.Telomerase is a reverse transcriptase enzyme that carries its own RNA molecule (e.g., with the sequence 3′-CCCAAUCCC-5′ in Trypanosoma brucei) which is used as a template when it elongates telomeres. Telomerase is active in gametes and most cancer cells, but is normally absent from, or at very low levels in, most somatic cells.

WikidataRate this definition:0.0 / 0 votes

1. Telomerase

   Telomerase is a ribonucleoprotein that is an enzyme which adds DNA sequence repeats to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. This region of repeated nucleotide called telomeres contains noncoding DNA and hinders the loss of important DNA from chromosome ends. As a result, every time the chromosome is copied only 100–200 nucleotides are lost, which causes no damage to the organism's DNA. Telomerase is a reverse transcriptase that carries its own RNA molecule, which is used as a template when it elongates telomeres, which are shortened after each replication cycle. The existence of a compensatory mechanism for telomere shortening was first predicted by Soviet biologist Alexey Olovnikov in 1973, who also suggested the telomere hypothesis of aging and the telomere's connections to cancer. Telomerase was discovered by Carol W. Greider and Elizabeth Blackburn in 1984 in the ciliate Tetrahymena. Together with Jack W. Szostak, Greider and Blackburn were awarded the 2009 Nobel Prize in Physiology or Medicine for their discovery.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Telomerase

   An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.

Matched Categories

1. • Enzyme

How to pronounce telomerase?

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How to say telomerase in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of telomerase in Chaldean Numerology is: 3

2. Pythagorean Numerology

   The numerical value of telomerase in Pythagorean Numerology is: 5

Examples of telomerase in a Sentence

1. Dean Ornish:

   We found that telomerase, the enzyme that repairs and lengthens telomeres, increased by 30% after just three months on the program, then we found that people who had been on the program for five years had telomeres that were about 10% longer, a sign that aging is being reversed on the cellular level.

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References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=telomerase
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Telomerase
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Telomerase
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=telomerase