A rapidly decreasing response to a drug following administration of the initial doses
Tachyphylaxis is a medical term describing an acute decrease in the response to a drug after its administration. Tachyphylaxis can occur both after an initial dose of medication or after an inoculation with a series of small doses. Increasing the dose of the drug may be able to restore the original response. This can sometimes be caused by depletion or marked reduction of the amount of neurotransmitter responsible for creating the drug's effect, or by the depletion of receptors available for the drug or neurotransmitter to bind to. This depletion is caused by the cell's reducing the number of receptors in response to their saturation. Some examples include amphetamine, ephedrine, and MDMA which act indirectly through the release of neurotransmitters.
U.S. National Library of Medicine
Rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. In immunology, it is the rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses. (Dorland, 28th ed)
The numerical value of tachyphylaxis in Chaldean Numerology is: 5
The numerical value of tachyphylaxis in Pythagorean Numerology is: 9
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"tachyphylaxis." Definitions.net. STANDS4 LLC, 2017. Web. 20 Oct. 2017. <http://www.definitions.net/definition/tachyphylaxis>.