2. (noun)sorrow, regret, rue, ruefulness sadness associated with some wrong done or some disappointment "he drank to drown his sorrows"; "he wrote a note expressing his regret"; "to his rue, the error cost him the game"
3. (noun)grief, sorrow something that causes greatunhappiness "her death was a great grief to John"
4. (noun)sadness, sorrow, sorrowfulness the state of being sad
"she tired of his perpetual sadness"