Definitions for proerythroblast
proe·ry·throb·last

WiktionaryRate this definition:4.0 / 1 vote

1. proerythroblastnoun

   The earliest stage in the development of a normoblast

WikipediaRate this definition:0.0 / 0 votes

1. Proerythroblast

   A proerythroblast (or rubriblast, or pronormoblast) is the earliest of four stages in development of the normoblast. In histology, it is very difficult to distinguish it from the other "-blast" cells (lymphoblast, myeloblast, monoblast, and megakaryoblast). The cytoplasm is blue in an H&E stain, indicating that it is basophilic. Proerythroblasts arise from the CFU-e (colony-forming unit erythroid) cells, and give rise to basophilic erythroblasts. In the mouse, proerythroblasts are large committed progenitors that express high levels of transferrin receptor (iron acquisition receptor), the erythropoietin receptor (EpoR), some c-Kit (stem cell factor receptor), and are Ter119 (cell surface molecule)-positive. Their proliferative capacity is more limited compared to the preceding stage, the CFU-e. In vivo, starting with the proerythroblast stage, erythroid cells undergo several more cell divisions while at the same time upregulating survival genes such as Bcl-xL, acquiring and storing large amounts of iron, ramping up the synthesis of hemoglobin and other erythroid genes (in large part a GATA-1 dependent process that is augmented by the EpoR signaling) and decreasing in cell size, eventually removing their nuclei and being released into the bloodstream as a reticulocyte. There are several Nucleoli on the nucleus and it occupies most of the cell volume. the chromatins are consist of a network of fine red pink strands. The distinguished feature of pro erythroblast to its corresponding myeloblast in granulocytic series is that it carries more basophilic peripheral cytoplasm.

WikidataRate this definition:0.0 / 0 votes

1. Proerythroblast

   A proerythroblast is the earliest of four stages in development of the normoblast. In histology, it is very difficult to distinguish it from the other "-blast" cells. The cytoplasm is blue in an H&E stain, indicating that it is basophilic. Proerythroblasts arise from the CFU-e cells, and give rise to basophilic erythroblasts. In the mouse, proerythroblasts are large committed progenitors that express high levels of transferrin receptor, the erythropoietin receptor, some c-Kit, and are Ter119-positive. Their proliferative capacity is more limited compared to the preceding stage, the CFU-e. In vivo, starting with the proerythroblast stage, erythroid cells undergo several more cell divisions while at the same time upregulating survival genes such as Bcl-xL, acquiring and storing large amounts of iron, ramping up the synthesis of hemoglobin and other erythroid genes and decreasing in cell size, eventually removing their nuclei and being released into the bloodstream as a reticulocyte.

How to pronounce proerythroblast?

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Numerology

1. Chaldean Numerology

   The numerical value of proerythroblast in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of proerythroblast in Pythagorean Numerology is: 5

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Proerythroblast
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Proerythroblast
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=proerythroblast