1. (noun)pioneer, innovator, trailblazer, groundbreaker someone who helps to open up a new line of research or technology or art
2. (noun)pioneer one the first colonists or settlers in a new territory "they went west as pioneers with only the possessions they could carry with them"
3. (verb)pioneer, open up open up an area or prepare a way "She pioneered a graduate program for women students"
4. (verb)initiate, pioneer take the lead or initiative in; participate in the development of "This South African surgeon pioneered heart transplants"
5. (verb)pioneer open up and explore a new area "pioneer space"