1. (noun)plague, pestilence, pest, pestis a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal
3. (noun)pest, blighter, cuss, pesterer, gadfly a persistently annoyingperson
4. (noun)pest any unwanted and destructive insect or other animal that attacks food or crops or livestock etc. "he sprayed the garden to get rid of pests"; "many pests have developed resistance to the common pesticides"