Definitions for perforin
A cytolytic protein found in natural killer cells
U.S. National Library of Medicine
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
Perforin-1 is a protein that in humans is encoded by the PRF1 gene.