Definitions for parkinson's disease
ˈpɑr kɪn səns; -səˌnɪz əmparkin·son's dis·ease

Princeton's WordNetRate this definition:0.0 / 0 votes

1. paralysis agitans, Parkinsonism, Parkinson's disease, Parkinson's syndrome, Parkinson's, shaking palsynoun

   a degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination

WikipediaRate this definition:0.0 / 0 votes

1. Parkinson's disease

   Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms become more common. The most obvious early symptoms are tremor, rigidity, slowness of movement, and difficulty with walking. Cognitive and behavioral problems may also occur with depression, anxiety, and apathy occurring in many people with PD. Parkinson's disease dementia becomes common in the advanced stages of the disease. Those with Parkinson's can also have problems with their sleep and sensory systems. The motor symptoms of the disease result from the death of nerve cells in the substantia nigra, a region of the midbrain, leading to a dopamine deficit. The cause of this cell death is poorly understood, but involves the build-up of misfolded proteins into Lewy bodies in the neurons. Collectively, the main motor symptoms are also known as parkinsonism or a parkinsonian syndrome.The cause of PD is unknown, but a combination of genetic factors, and environmental factors are believed to play a role. Those with an affected family member are at an increased risk of getting the disease, with certain genes known to be inheritable risk factors. Environmental risk factors of note are exposure to pesticides, and prior head injuries. Coffee drinkers, tea drinkers, and tobacco smokers are at a reduced risk.Diagnosis of typical cases is mainly based on symptoms, with motor symptoms being the chief complaint. Tests such as neuroimaging (magnetic resonance imaging or imaging to look at dopamine neuronal dysfunction known as DaT scan) can be used to help rule out other diseases. Parkinson's disease typically occurs in people over the age of 60, of whom about one percent are affected. Males are more often affected than females at a ratio of around 3:2. When it is seen in people before the age of 50, it is called early-onset PD. By 2015, PD affected 6.2 million people and resulted in about 117,400 deaths globally. The number of people with PD older than fifty is expected to double by 2030. The average life expectancy following diagnosis is between 7 and 15 years.No cure for PD is known; treatment aims to reduce the effects of the symptoms. Initial treatment is typically with the medications levodopa (L-DOPA), MAO-B inhibitors, or dopamine agonists. As the disease progresses, these medications become less effective, while at the same time producing a side effect marked by involuntary muscle movements. At that time, medications may be used in combination and doses may be increased. Diet and certain forms of rehabilitation have shown some effectiveness at improving symptoms. Surgery to place microelectrodes for deep brain stimulation has been used to reduce motor symptoms in severe cases where drugs are ineffective. Evidence for treatments for the nonmovement-related symptoms of PD, such as sleep disturbances and emotional problems, is less strong.The disease is named after English doctor James Parkinson, who published the first detailed description in An Essay on the Shaking Palsy, in 1817. Public awareness campaigns include World Parkinson's Day (on the birthday of James Parkinson, 11 April) and the use of a red tulip as the symbol of the disease. People with PD who have increased the public's awareness of the condition include boxer Muhammad Ali, comedian Billy Connolly, actor Michael J. Fox, Olympic cyclist Davis Phinney, and actor Alan Alda.

ChatGPTRate this definition:0.0 / 0 votes

1. parkinson's disease

   Parkinson's disease is a progressive, neurodegenerative disorder that primarily affects movement control. It occurs when certain nerve cells in the brain, known as neurons, break down or die. Most symptoms of the disease are due to a loss of neurons that produce dopamine, a chemical messenger in the brain. Common symptoms include tremors, stiffness, slowness of movement, impaired balance, and a decrease in automatic movement. The disease may also cause non-movement related symptoms like anxiety, depression, and cognitive changes. Though the exact cause of Parkinson's is unknown, both genetic and environmental factors are believed to play a role. While currently incurable, medication and therapy can often significantly improve symptoms.

WikidataRate this definition:0.0 / 0 votes

1. Parkinson's disease

   Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with walking and gait. Later, thinking and behavioral problems may arise, with dementia commonly occurring in the advanced stages of the disease, whereas depression is the most common psychiatric symptom. Other symptoms include sensory, sleep and emotional problems. Parkinson's disease is more common in the elderly, with most cases occurring after the age of 50. The main motor symptoms are collectively called parkinsonism, or a "parkinsonian syndrome". Parkinson's disease is often defined as a parkinsonian syndrome that is idiopathic, although some atypical cases have a genetic origin. Many risk and protective factors have been investigated: the clearest evidence is for an increased risk of PD in people exposed to certain pesticides and a reduced risk in tobacco smokers. The pathology of the disease is characterized by the accumulation of a protein called alpha-synuclein into inclusions called Lewy bodies in neurons, and from insufficient formation and activity of dopamine produced in certain neurons within parts of the midbrain. Lewy bodies are the pathological hallmark of the idiopathic disorder, and the distribution of the Lewy bodies throughout the Parkinsonian brain varies from one individual to another. The anatomical distribution of the Lewy bodies is often directly related to the expression and degree of the clinical symptoms of each individual. Diagnosis of typical cases is mainly based on symptoms, with tests such as neuroimaging being used for confirmation.

Matched Categories

1. • Brain Disorder
   • Degenerative Disorder

How to pronounce parkinson's disease?

1. Alex

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   David

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How to say parkinson's disease in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of parkinson's disease in Chaldean Numerology is: 5

2. Pythagorean Numerology

   The numerical value of parkinson's disease in Pythagorean Numerology is: 9

Examples of parkinson's disease in a Sentence

1. Filip Bergquist:

   What we are hoping for with this device is to find a treatment for movement disorders where Levodopa, Parkinson's disease where Levodopa is not enough. And in particular in patients with Parkinson's disease where there is problem with gait and balance. But this may not be restricted to Parkinson's disease, so there may be other conditions with poor balance where you could use electrical stimulation of the vestibular organs, the balance organs to improve balance and gait.

2. Hyon Choi:

   As a major natural antioxidant in the body, uric acid has been estimated to account for more than 50 percent of the antioxidant capacity of plasma, with these potentially neuro-protective properties, uric acid has been hypothesized to protect against oxidative stress, a prominent contributor to dopaminergic neuron degeneration in Parkinson's disease, which may also play an important role in the pathogenesis of Alzheimer’s disease.

3. Hyunsoo Shawn Je:

   These experiments are the first to recreate the distinctive features of Parkinson’s disease that we see only in human patients, we have created a new model of the pathology involved, which will allow us to track how the disease develops and how it might be slowed down or stopped.

4. Hyon Choi:

   If confirmed by future studies, a therapeutic investigation that has been employed to prevent progression of Parkinson's disease may be warranted for this relatively common and devastating condition.

5. James Beck:

   Understanding where that 20 % is coming from could be useful in the bigger scheme of things for all people with Parkinson's disease.

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=parkinson's disease
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Parkinson'S_Disease
3. ^ ChatGPT
   https://chat.openai.com
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=parkinson's disease