What does paralysis, hyperkalemic periodic mean?
Definitions for paralysis, hyperkalemic periodic
para·ly·sis, hy·per·kalemic pe·ri·od·ic
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Wikipedia
paralysis, hyperkalemic periodic
Hyperkalemic periodic paralysis (HYPP, HyperKPP) is an inherited autosomal dominant disorder that affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood. It is characterized by muscle hyperexcitability or weakness which, exacerbated by potassium, heat or cold, can lead to uncontrolled shaking followed by paralysis. Onset usually occurs in early childhood, but it still occurs with adults. The mutation which causes this disorder is dominant on SCN4A with linkage to the sodium channel expressed in muscle. The mutation causes single amino acid changes in parts of the channel which are important for inactivation. These mutations impair "ball and chain" fast inactivation of SCN4A following an action potential.
U.S. National Library of Medicine
Paralysis, Hyperkalemic Periodic
An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)
Numerology
Chaldean Numerology
The numerical value of paralysis, hyperkalemic periodic in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of paralysis, hyperkalemic periodic in Pythagorean Numerology is: 1
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