What does nonsynonymous substitution mean?
Definitions for nonsynonymous substitution
non·syn·ony·mous sub·sti·tu·tion
This dictionary definitions page includes all the possible meanings, example usage and translations of the word nonsynonymous substitution.
Wikipedia
Nonsynonymous substitution
A nonsynonymous substitution is a nucleotide mutation that alters the amino acid sequence of a protein. Nonsynonymous substitutions differ from synonymous substitutions, which do not alter amino acid sequences and are (sometimes) silent mutations. As nonsynonymous substitutions result in a biological change in the organism, they are subject to natural selection. Nonsynonymous substitutions at a certain locus can be compared to the synonymous substitutions at the same locus to obtain the Ka/Ks ratio. This ratio is used to measure the evolutionary rate of gene sequences. If a gene has lower levels of nonsynonymous than synonymous nucleotide substitution, then it can be inferred to be functional because a Ka/Ks ratio < 1 is a hallmark of sequences that are being constrained to code for proteins. Nonsynonymous substitutions are also referred to as replacement mutations.
Numerology
Chaldean Numerology
The numerical value of nonsynonymous substitution in Chaldean Numerology is: 6
Pythagorean Numerology
The numerical value of nonsynonymous substitution in Pythagorean Numerology is: 7
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"nonsynonymous substitution." Definitions.net. STANDS4 LLC, 2024. Web. 30 Apr. 2024. <https://www.definitions.net/definition/nonsynonymous+substitution>.
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