Definitions for nonsense mutation
non·sense mu·ta·tion

WiktionaryRate this definition:0.0 / 0 votes

1. nonsense mutationnoun

   A point mutation that generates either a premature stop codon, or a codon that does not specify any amino acid.

WikipediaRate this definition:0.0 / 0 votes

1. Nonsense mutation

   In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed mRNA, and in leading to a truncated, incomplete, and nonfunctional protein product. Nonsense mutation is not always harmful, the functional effect of a nonsense mutation depends on many aspects, such as the location of the stop codon within the coding DNA. For example, the effect of a nonsense mutation depends on the proximity of the nonsense mutation to the original stop codon, and the degree to which functional subdomains of the protein are affected. As nonsense mutations leads to premature termination of polypeptide chains; they are also called chain termination mutations.Missense mutations differ from nonsense mutations since they are point mutations that exhibit a single nucleotide change to cause substitution of a different amino acid. A nonsense mutation also differs from a nonstop mutation, which is a point mutation that removes a stop codon. About 10% of patients facing genetic diseases have involvement with nonsense mutations. Some of the diseases that these mutations can cause are Duchenne muscular dystrophy (DMD), cystic fibrosis (CF), spinal muscular atrophy (SMA), cancers, metabolic diseases, and neurologic disorders. The rate of nonsense mutations is variable from gene-to-gene and tissue-to-tissue but gene silencing occurs in every patient with a nonsense mutation.

WikidataRate this definition:0.0 / 0 votes

1. Nonsense mutation

   In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed mRNA, and in a truncated, incomplete, and usually nonfunctional protein product. It differs from a missense mutation, which is a point mutation where a single nucleotide is changed to cause substitution of a different amino acid. Some genetic disorders, such as thalassemia and DMD, result from nonsense mutations.

How to pronounce nonsense mutation?

1. Alex

   US English

   David

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   Mark

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   Daniel

   British

   Libby

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   Mia

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   Karen

   Australian

   Hayley

   Australian

   Natasha

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   Indian

   Priya

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   Neerja

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   Zira

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   Oliver

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How to say nonsense mutation in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of nonsense mutation in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of nonsense mutation in Pythagorean Numerology is: 2

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Nonsense_Mutation
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Nonsense_Mutation
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=nonsense mutation