What does no-observed-adverse-effect level mean?
Definitions for no-observed-adverse-effect level
no-ob·served-ad·verse-ef·fect lev·el
This dictionary definitions page includes all the possible meanings, example usage and translations of the word no-observed-adverse-effect level.
Wikipedia
No-observed-adverse-effect level
The no-observed-adverse-effect level (NOAEL) denotes the level of exposure of an organism, found by experiment or observation, at which there is no biologically or statistically significant increase in the frequency or severity of any adverse effects of the tested protocol. In drug development, the NOAEL of a new drug is assessed in laboratory animals, such as mice, prior to initiation of human trials in order to establish a safe clinical starting dose in humans. The OECD publishes guidelines for Preclinical Safety Assessments, in order to help scientists discover the NOAEL.
U.S. National Library of Medicine
No-Observed-Adverse-Effect Level
The highest dosage administered that does not produce toxic effects. The NOAEL will depend on how closely dosages are spaced (lowest-observed-adverse-effect level and no-observed-effect level) and the number of animals examined. The ultimate objective is usually to determine not the "safe" dosage in laboratory animals but the "safe" dosage for humans. Therefore, the extrapolation most often required of toxicologists is from high-dosage studies in laboratory animals to low doses in humans. (Casarett and Doull's Toxicology: The Basic Science of Poisons, 4th ed)
Numerology
Chaldean Numerology
The numerical value of no-observed-adverse-effect level in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of no-observed-adverse-effect level in Pythagorean Numerology is: 6
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"no-observed-adverse-effect level." Definitions.net. STANDS4 LLC, 2024. Web. 28 Apr. 2024. <https://www.definitions.net/definition/no-observed-adverse-effect+level>.
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