Definitions for naltrexonenælˈtrɛk soʊn
Random House Webster's College Dictionary
a nonaddictive substance, C20H23NO4, used in the treatment of heroin addiction and opiate overdose.
Origin of naltrexone:
1970–75; by rearrangement of parts of its chemical name
an oral antagonist against the action of opiates
An opiate antagonist used to treat opioid dependence
Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. It is marketed in generic form as its hydrochloride salt, naltrexone hydrochloride, and marketed under the trade names Revia and Depade. In some countries including the United States, a once-monthly extended-release injectable formulation is marketed under the trade name Vivitrol. Also in the US, Methylnaltrexone Bromide, a closely related drug, is marketed as Relistor, for the treatment of opioid induced constipation. Naltrexone should not be confused with naloxone nor nalorphine. Using naloxone in place of naltrexone can cause acute opioid withdrawal symptoms; conversely, using naltrexone in place of naloxone in an overdose can lead to insufficient opioid antagonism and fail to reverse the overdose.
U.S. National Library of Medicine
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
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