What does miglustat mean?
Definitions for miglustat
miglu·s·tat
This dictionary definitions page includes all the possible meanings, example usage and translations of the word miglustat.
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Wiktionary
miglustatnoun
A drug used primarily to treat certain kinds of Gaucher's disease by inhibiting glucosylceramide synthase, an essential enzyme for the synthesis of most glycosphingolipids.
Wikidata
Miglustat
Miglustat is a drug developed by Actelion and is used primarily to treat Type 1 Gaucher disease. It is marketed under the trade name Zavesca. Miglustat is an imino sugar, a synthetic analogue of D-glucose and a white to off-white crystalline solid that has a bitter taste The primary pharmacological activity of miglustat is inhibition of the enzyme glucosylceramide synthase, catalyzing the first step in the biosynthesis of glycosphingolipids, i.e., the formation of glucosylceramide. Reduced formation of GlcCer will lead to decreased biosynthesis of more complex GSL. This therapeutic principle, called substrate reduction therapy, may be useful in disorders of intracellular accumulation of GSL either due to their deficient breakdown or intracellular transport/trafficking. Miglustat exhibits a large volume of distribution and has the capacity to access deep organs such as the brain, bone and lung. Miglustat inhibits glucosylceramide synthase, an essential enzyme for the synthesis of most glycosphingolipids. Miglustat is used to treat adults with mild to moderate type 1 Gaucher disease and it is the first treatment to be approved for patients with Niemann-Pick type C disease. Miglustat may only be used in the treatment of type 1 Gaucher patients for whom enzyme replacement therapy is unsuitable and it's been approved in the European Union for the treatment of progressive neurological manifestations in adult or pediatric patients with Niemann-Pick type C disease. It has also been approved for NPC treatment in Canada, Switzerland, Brazil, Australia, Turkey and Israel but not in the United States.
Numerology
Chaldean Numerology
The numerical value of miglustat in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of miglustat in Pythagorean Numerology is: 5
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"miglustat." Definitions.net. STANDS4 LLC, 2024. Web. 4 May 2024. <https://www.definitions.net/definition/miglustat>.
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