Definitions for methoxyflurane
methoxyflu·rane

WiktionaryRate this definition:0.0 / 0 votes

1. methoxyfluranenoun

   An inhalational anaesthetic of the 1960s and early 1970s, now largely abandoned because of detrimental effects on the kidneys.

WikipediaRate this definition:0.0 / 0 votes

1. Methoxyflurane

   Methoxyflurane, sold under the brand name Penthrox among others, is an inhaled medication primarily used to reduce pain following trauma. It may also be used for short episodes of pain as a result of medical procedures. Onset of pain relief is rapid and of a short duration. Use is only recommended with direct medical supervision.Common side effects include anxiety, headache, sleepiness, cough, and nausea. Serious side effects may include kidney problems, liver problems, low blood pressure, and malignant hyperthermia. It is unclear if it is safe in either pregnancy or breastfeeding. It is only recommended in those who have a normal level of consciousness and stable blood pressure and heart rate. It is classified as a volatile anaesthetic.It was first made in 1948 by William T. Miller and came into medical use in the 1960s. It was used as a general anesthetic from its introduction in 1960 until the late 1970s. In 1999, the manufacturer discontinued methoxyflurane in the United States, and in 2005 the Food and Drug Administration withdrew it from the market. It is still used in New Zealand, Australia, Ireland, and the United Kingdom for pain.

WikidataRate this definition:0.0 / 0 votes

1. Methoxyflurane

   Methoxyflurane, formerly marketed as Penthrane by Abbott Laboratories, is a halogenated ether that was in clinical use as a volatile inhalational anesthetic from its introduction by Joseph F. Artusio et al in 1960 until the late 1970s. It was first synthesized in the late 1940s by William T. Miller and his team of chemists following their involvement in the Manhattan Project. Methoxyflurane is an extremely potent and highly lipid soluble anesthetic agent, characterized by very slow induction and emergence times. It is non-flammable, has relatively mild hemodynamic effects, and it does not predispose the heart to rhythm disturbances. It is however a significant respiratory depressant. Methoxyflurane has powerful analgesic properties at well below full anesthetic doses. It was utilized in self-administration devices for obstetric analgesia, in a manner that foreshadowed the patient-controlled analgesia infusion pumps of today. The biodegradation of methoxyflurane produces inorganic fluoride and dichloroacetic acid. The combined effects of these two compounds may be responsible for the toxicity of methoxyflurane to some of the major organs of the human body. Methoxyflurane was determined to be nephrotoxic in a dose-dependent response and hepatotoxic at anesthetic doses in 1973, and the drug was abandoned as a general anesthetic in the late 1970s. In 1999, the manufacturer discontinued distribution of methoxyflurane in the United States and Canada, and on September 6, 2005, the Food and Drug Administration determined that it should be withdrawn from the market for safety concerns. It is however still used in Australia as an emergency analgesic for the initial management of pain due to acute trauma, as well as for brief painful procedures such as changing of wound dressings or for transport of injured people.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Methoxyflurane

   An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)

How to pronounce methoxyflurane?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

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   Fred

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   Tessa

   South African

How to say methoxyflurane in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of methoxyflurane in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of methoxyflurane in Pythagorean Numerology is: 7

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Methoxyflurane
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Methoxyflurane
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=methoxyflurane