Definitions for macrophage
ˈmæk rəˌfeɪdʒmacrophage

Princeton's WordNetRate this definition:0.0 / 0 votes

1. macrophagenoun

   a large phagocyte; some are fixed and other circulate in the blood stream

WiktionaryRate this definition:0.0 / 0 votes

1. macrophagenoun

   A white blood cell that phagocytizes necrotic cell debris and foreign material, including viruses, bacteria, and tattoo ink. It presents foreign antigens on MHC II to lymphocytes. Part of the innate immune system.

WikipediaRate this definition:0.0 / 0 votes

1. Macrophage

   Macrophages (abbreviated as Mφ, MΦ or MP) (Greek: large eaters, from Greek μακρός (makrós) = large, φαγεῖν (phagein) = to eat) are a type of white blood cell of the innate immune system that engulfs and digests pathogens, such as cancer cells, microbes, cellular debris, and foreign substances, which do not have proteins that are specific to healthy body cells on their surface. The process is called phagocytosis, which acts to defend the host against infection and injury.These larges are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microglia, and others), but all are part of the mononuclear phagocyte system. Besides phagocytosis, they play a critical role in nonspecific defense (innate immunity) and also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes. For example, they are important as antigen presenters to T cells. In humans, dysfunctional macrophages cause severe diseases such as chronic granulomatous disease that result in frequent infections. Beyond increasing inflammation and stimulating the immune system, macrophages also play an important anti-inflammatory role and can decrease immune reactions through the release of cytokines. Macrophages that encourage inflammation are called M1 macrophages, whereas those that decrease inflammation and encourage tissue repair are called M2 macrophages. This difference is reflected in their metabolism; M1 macrophages have the unique ability to metabolize arginine to the "killer" molecule nitric oxide, whereas M2 macrophages have the unique ability to metabolize arginine to the "repair" molecule ornithine. However, this dichotomy has been recently questioned as further complexity has been discovered.Human macrophages are about 21 micrometres (0.00083 in) in diameter and are produced by the differentiation of monocytes in tissues. They can be identified using flow cytometry or immunohistochemical staining by their specific expression of proteins such as CD14, CD40, CD11b, CD64, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68.Macrophages were first discovered and named by Élie Metchnikoff, a Russian zoologist, in 1884.

ChatGPTRate this definition:0.0 / 0 votes

1. macrophage

   A macrophage is a type of white blood cell found in the immune system, that engulfs and digests foreign substances, microbes, and cancer cells as part of the body's defense mechanism against infection and diseases. They also play a key role in triggering inflammation and stimulating other immune cells. Macrophages are prominent in various tissues, particularly in those areas exposed to external environments like the skin and intestinal lining. They can also change their functionality based on signals they receive, allowing them to respond to a range of different challenges, making them essential for maintaining body's homeostasis.

WikidataRate this definition:0.0 / 0 votes

1. Macrophage

   Macrophages are cells produced by the differentiation of monocytes in tissues. Macrophages were discovered by Ilya Mechnikov, a Russian bacteriologist, in 1884. Human macrophages are about 21 micrometres in diameter. Monocytes and macrophages are phagocytes. Macrophages function in both non-specific defense as well as help initiate specific defense mechanisms of vertebrate animals. Their role is to phagocytose, or engulf and then digest, cellular debris and pathogens, either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens. They are specialized phagocytic cells that attack foreign substances, infectious microbes and cancer cells through destruction and ingestion. Macrophages can be identified by specific expression of a number of proteins including CD14, CD40, CD11b, CD64, F4/80 /EMR1, lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining. They move by action of amoeboid movement.

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1. • Phagocyte

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1. cameograph

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Numerology

1. Chaldean Numerology

   The numerical value of macrophage in Chaldean Numerology is: 3

2. Pythagorean Numerology

   The numerical value of macrophage in Pythagorean Numerology is: 6

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References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=macrophage
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Macrophage
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Macrophage
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=macrophage