Definitions for macrophageˈmæk rəˌfeɪdʒ
This page provides all possible meanings and translations of the word macrophage
Random House Webster's College Dictionary
a large white blood cell, occurring principally in connective tissue and in the bloodstream, that ingests foreign particles and infectious microorganisms by phagocytosis.
Category: Histology, Laboratory Biology, Cell Biology
Origin of macrophage:
< G Makrophagen (pl.) (Metchnikoff, 1887), with -phagen repr. Phagozyten phagocytes; see macro -, -phage
a large phagocyte; some are fixed and other circulate in the blood stream
A white blood cell that phagocytizes necrotic cell debris and foreign material, including viruses, bacteria, and tattoo ink. It presents foreign antigens on MHC II to lymphocytes. Part of the innate immune system.
Macrophages are cells produced by the differentiation of monocytes in tissues. Macrophages were discovered by Ilya Mechnikov, a Russian bacteriologist, in 1884. Human macrophages are about 21 micrometres in diameter. Monocytes and macrophages are phagocytes. Macrophages function in both non-specific defense as well as help initiate specific defense mechanisms of vertebrate animals. Their role is to phagocytose, or engulf and then digest, cellular debris and pathogens, either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens. They are specialized phagocytic cells that attack foreign substances, infectious microbes and cancer cells through destruction and ingestion. Macrophages can be identified by specific expression of a number of proteins including CD14, CD40, CD11b, CD64, F4/80 /EMR1, lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining. They move by action of amoeboid movement.
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