Definitions for lithocholic acid
litho·cholic acid

WiktionaryRate this definition:0.0 / 0 votes

1. lithocholic acidnoun

   The bile acid 3u03B1-hydroxy-5u03B2-cholan-24-oic acid, which acts as a detergent to solubilize fats for absorption.

WikipediaRate this definition:0.0 / 0 votes

1. Lithocholic acid

   Lithocholic acid, also known as 3α-hydroxy-5β-cholan-24-oic acid or LCA, is a bile acid that acts as a detergent to solubilize fats for absorption. Bacterial action in the colon produces LCA from chenodeoxycholic acid by reduction of the hydroxyl functional group at carbon-7 in the "B" ring of the steroid framework.It has been implicated in human and experimental animal carcinogenesis. Preliminary in vitro research suggests that LCA selectively kills neuroblastoma cells, while sparing normal neuronal cells and is cytotoxic to numerous other malignant cell types at physiologically relevant concentrations.Dietary fiber can bind to lithocholic acid and aid in its excretion in stool; as such, fiber can protect against colon cancer. LCA (and LCA acetate and LCA propionate) can activate the vitamin D receptor without raising calcium levels as much as vitamin D itself.LCA binds with high affinity (20 μM) to the human membrane enzyme NAPE-PLD, enhancing dimer assembly and enabling catalysis. NAPE-PLD catalyzes the release of anandamide and other N-acylethanolamines (NAE) from the membrane precursor N-acyl-phosphatidylethanolamine(NAPE). NAPE-PLD facilitates crosstalk between bile acid signals and lipid amide signals. LCA was also shown to have anti-aging effects in a yeast study. A later study showed that the bile acid accumulates in the inner and outer mitochondrial membranes, altering the mitochondria's lipid composition by promoting or inhibiting various enzymes.

WikidataRate this definition:0.0 / 0 votes

1. Lithocholic acid

   Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption. Bacterial action in the colon produces LCA from chenodeoxycholic acid by reduction of the hydroxyl functional group at carbon-7 in the "B" ring of the steroid framework. It has been implicated in human and experimental animal carcinogenesis. Preliminary in vitro research suggests that LCA selectively kills neuroblastoma cells, while sparing normal neuronal cells and is cytotoxic to numerous other malignant cell types at physiologically relevant concentrations. Dietary fiber can bind to lithocholic acid and aid in its excretion in stool; as such, fiber can protect against colon cancer. LCA can activate the vitamin D receptor without raising calcium levels as much as vitamin D itself.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Lithocholic Acid

   A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.

How to pronounce lithocholic acid?

1. Alex

   US English

   David

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   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say lithocholic acid in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of lithocholic acid in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of lithocholic acid in Pythagorean Numerology is: 5

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Lithocholic_Acid
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Lithocholic_Acid
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=lithocholic acid