Definitions for lipoic acid
lipoic acid

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1. lipoic acidnoun

   A chemical compound, IUPAC name 5-[(3R)-dithiolan-3-yl]pentanoic acid, one enantiomer of which is an essential cofactor for many enzyme complexes.

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1. Lipoic acid

   Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). ALA is made in animals normally, and is essential for aerobic metabolism. It is also manufactured and is available as a dietary supplement in some countries where it is marketed as an antioxidant, and is available as a pharmaceutical drug in other countries. Lipoate is the conjugate base of lipoic acid, and the most prevalent form of LA under physiological conditions. Only the (R)-(+)-enantiomer (RLA) exists in nature and is essential for aerobic metabolism because RLA is an essential cofactor of many enzyme complexes.

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1. Lipoic acid

   Lipoic acid, also known as α-lipoic acid and alpha lipoic acid is an organosulfur compound derived from octanoic acid. LA contains two sulfur atoms connected by a disulfide bond and is thus considered to be oxidized although either sulfur atom can exist in higher oxidation states. The carbon atom at C6 is chiral and the molecule exists as two enantiomers--lipoic acid and--lipoic acid and as a racemic mixture-lipoic acid. Only the--enantiomer exists in nature and is an essential cofactor of four mitochondrial enzyme complexes. Endogenously synthesized RLA is essential for aerobic metabolism. Both RLA and R/S-LA are available as over-the-counter nutritional supplements and have been used nutritionally and clinically since the 1950s for various diseases and conditions. LA appears physically as a yellow solid and structurally contains a terminal carboxylic acid and a terminal dithiolane ring. The relationship between endogenously synthesized RLA and administered free RLA or R/S-LA has not been fully characterized but free plasma and cellular levels increase and decrease rapidly after oral consumption or intravenous injections. "Lipoate" is the conjugate base of lipoic acid, and the most prevalent form of LA under physiologic conditions. Although the intracellular environment is strongly reducing, both free LA and its reduced form, dihydrolipoic acid, have been detected in cells after administration of LA. Most endogenously produced RLA is not “free” because octanoic acid, the precursor to RLA, is bound to the enzyme complexes prior to enzymatic insertion of the sulfur atoms. As a cofactor, RLA is covalently attached by an amide bond to a terminal lysine residue of the enzyme’s lipoyl domains. One of the most studied roles of RLA is as a cofactor of the pyruvate dehydrogenase complex, though it is a cofactor in other enzymatic systems as well.

How to pronounce lipoic acid?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say lipoic acid in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of lipoic acid in Chaldean Numerology is: 5

2. Pythagorean Numerology

   The numerical value of lipoic acid in Pythagorean Numerology is: 9

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Lipoic_Acid
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Lipoic_Acid
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=lipoic acid